- Docencia
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Programas Académicos de Pregrado
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Programas Académicos de Post Grado
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- Programas de educación continua
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- Laboratorios
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Dra. Katherine Marcelain.
Perfil Academico
Profesora asociada
Facultad de Medicina. Universidad de Chile.
Grados y Postgrados:
MÉDICO VETERINARIO. DOCTOR EN CIENCIAS BIOMÉDICAS
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Proyectos
FONDEF IDEA TumorSec: Optimización, validación y masificación de un ensayo de secuenciación de genes para mejorar la precisión de terapias oncológicas. (01-03-2017 / 01-03-2019) K. Marcelain / R. Verdugo UCH / Facultad de Medicina, Departamento de Oncología Básico _ Clínico, Departamento de Oncología Básico _ Clínico
FONDECYT Regular ADAR promotes breast cancer progression through the regulation of cell cycle and DNA repair related genes (01-03-2015 / 01-03-2019) R. Armisen / B. Muller; J. Tapia; K. Marcelain; R. Verdugo Otras Instituciones/ Otras Instituciones, Otras Instituciones FONDECYT Regular Role of Ski/Smad4 complex on the establishment of epigenetic modifications of pericentromeric chromatin required for proper chromosome segregation. (01-03-2015 / 01-03-2019) K. Marcelain / R. Armisen; R. Assar. UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana
FONDEQUIP Concurso de Equipamiento Científico NextSeq 5000 Sequencing System (01-11-2014 / 01-11-2015) R. Verdugo / A. Couve; B. Urzua; C. Araneda; C. Larrañaga; J. Aguillon; K. Marcelain; L. Cifuentes; L. Herrera; L. Jara; M. Bustamante; P. Olguín; R. Armisen; R. Ramires; S. Lavandero UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana
FONDEQUIP Concurso de Equipamiento Científico Plataforma de microscopía confocal para uso en investigaciones biomédicas avanzadas (01-12-2013 / 01-12-2014) L. Leyton / A. Criollo; A. Paula; D. Bravo; E. Jaimovich; G. Diaz; K. Marcelain; M. Behrens; M. Chiong; M. Vega; S. Buvinic; S. Lavandero; U. Kemmerling; V. Torres UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular FONDEQUIP Concurso de Equipamiento Científico
Programa de Investigación Asociativa Concurso Anillos en Ciencia y Tecnologia Física de Plasma, Potencia Pulsada y Biología Celular para Energía, Vida y Medio Ambiente (01-10-2012 / 01-10-2015) L. Soto / A. Tarifeño; C. Pavez; G. Aravía; G. Gutiérrez; J. Moreno; J. Tapia; K. Marcelain; L. Huerta; M. Zambra; R. Armisen Comisión Chilena de Energía Núclear/ Comisión Chilena de Energía Núclear, Comisión Chilena de Energía Núclear
FONDECYT Regular Ski-containing transciptional co-repressor complexes on mitotic chromosomes repress the expression of selected target genes at early G1 (01-03-2012 / 01-03-2015) K. Marcelain / R. Armisen; U. Urzua UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana
FONDECYT Regular The transient receptor potential melastatin 4 (TRPM4) channel stabilizes beta-catenin and therefore enhances cell proliferation through a calcium-dependent negative regulation of GSK-3beta activity (01-03-2012 / 01-03-2015) R. Armisen / J. Tapia; K. Marcelain UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Fisiopatología
Fondo Central de Investigación Programa U-Redes: Línea 2 incentivo a la Consolidación de Red; Domeyko II Red de medicina traslacional en Cáncer (U-CANCER) (01-11-2011 / 01-11-2012) R. Armisen / A. Quest; A. Villavicencio; C. Fernández; E. Castellon; F. ALONSO; F. Salazar; H. Contreras; I. Gallegos; J. Fernández; J. Tapia; K. Marcelain; M. Ahumada; M. Galindo; M. Lopez; O. Barajas; V. Cristi; V. Torres UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Fisiopatología
Fondo Central de Investigación INICIACION La quinasa Aurora-A fosforila Ski induciendo su degradación proteosomal durante la mitosis. (01-10-2007 / 01-10-2009) K. Marcelain UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana
Publicaciones
- Cappelli, C; Sepulveda, H; Rivas, S; Pola, V; Urzua, U; Donoso, G; Sagredo, E; Carrero, D; Casanova-Ortiz, E; Sagredo, A; Gonzalez, M; Manterola, M; Nardocci, G; Armisen, R; Montecino, M; Marcelain, K. Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts 2020 JOURNAL OF MOLECULAR BIOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1016/j.jmb.2020.03.013
- Sagredo, EA; Sagredo, AI; Blanco, A; De Santiago, PR; Rivas, S; Assar, R; Perez, P; Marcelain, K; Armisen, R. ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response 2020 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1016/j.bbamcr.2020.118716
- Boekstegers F., Marcelain K., Barahona Ponce C., Baez Benavides P.F., Müller B., de Toro G., Retamales J., Barajas O., Ahumada M., Morales E., Rojas A., Sanhueza V., Loader D., Rivera M.T., Gutiérrez L., Bernal G., Ortega A., Montalvo D., Portiño S., Bertrán M.E., Gabler F., Spencer L., Olloquequi J., González Silos R., Fischer C., Scherer D., Jenab M., Aleksandrova K., Katzke V., Weiderpass E., Moradi T., Fischer K., Bossers W., Brenner H., Hveem K., Eklund N., Völker U., Waldenberger M., Fuentes Guajardo M., Gonzalez-Jose R., Bedoya G., Bortolini M.C., Canizales S., Gallo C., Ruiz Linares A., Rothhammer F., Lorenzo Bermejo J. ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans. 2020 CANCER EPIDEMIOLOGY SCOPUS/UCH/VID http://dx.doi.org/10.1016/j.canep.2019.101643
- Schafer, CE; Santibanez, A; Gutierrez-Gonzalez, M; Toro, J; Marcelain, K; Howell, AR; Porcelli, SA; Carreno, LJ iNKT cell stimulation by glycolipid ligands modified from alpha-galactosylceramide results in differential interleukin-2 secretion profiles. JOURNAL OF IMMUNOLOGY ISI/UCH/VID
- Sagredo, AI; Sagredo, EA; Pola, V; Echeverria, C; Andaur, R; Michea, L; Stutzin, A; Simon, F; Marcelain, K; Armisen, R. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines 2019 JOURNAL OF CELLULAR PHYSIOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/jcp.27371
- Sagredo, AI; Sagredo, EA; Cappelli, C; Baez, P; Andaur, RE; Blanco, C; Tapia, JC; Echeverria, C; Cerda, O; Stutzin, A; Simon, F; Marcelain, K; Armisen, R TRPM4 regulates Akt/GSK3-beta activity and enhances beta-catenin signaling and cell proliferation in prostate cancer cells. 2018 MOLECULAR ONCOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/1878-0261.12100
- Aracena, M; Cares, C; Arredondo, S; Marcelain, K; Gonzalez-Hormazabal, P NIJMEGEN BREAKAGE SYNDROME: FOLLOW UP OF SEVEN CASES IN CHILE 2018 AMERICAN JOURNAL OF MEDICAL GENETICS PART A ISI/UCH/VID
- Sagredo, EA; Blanco, A; Sagredo, AI; Perez, P; Sepulveda-Hermosilla, G; Morales, F; Muller, B; Verdugo, R; Marcelain, K; Harismendy, O; Armisen, R ADAR1-mediated RNA-editing of 3 ‘ UTRs in breast cancer 2018 BIOLOGICAL RESEARCH ISI;SCOPUS;SCIELO-Chile/UCH/VID http://dx.doi.org/10.1186/s40659-018-0185-4
- Andaur R., Tapia J.C., Moreno J., Soto L., Armisen R., Marcelain K. Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells 2018 ONCOTARGET SCOPUS/UCH/VID http://dx.doi.org/10.18632/oncotarget.25405
- Jain J., Moreno J., Andaur R., Armisen R., Avaria G., Bora B., Davis S., Pavez C., Marcelain K., Soto L. In vitro irradiation of colorectal cancer cells by pulsed radiation emitted from a hundred joules plasma focus device and its comparison with continuous irradiation 2018 Journal of Physics: Conference Series SCOPUS/UCH/VID http://dx.doi.org/10.1088/1742-6596/1043/1/012047
- Bermejo, JL; Boekstegers, F; Silos, RG; Marcelain, K; Benavides, PB; Ponce, CB; Muller, B; Ferreccio, C; Koshiol, J; Fischer, C; Peil, B; Sinsheimer, J; Guajardo, MF; Barajas, O; Gonzalez-Jose, R; Bedoya, G; Bortolini, MC; Canizales-Quinteros, S; Gallo, C; Linares, AR; Rothhammer, F Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile 2017 PLOS GENETICS ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1371/journal.pgen.1006756
- Jain, J; Moreno, J; Andaur, R; Armisen, R; Morales, D; Marcelain, K; Avaria, G; Bora, B; Davis, S; Pavez, C; Soto, L. Hundred joules plasma focus device as a potential pulsed source for in vitro cancer cell irradiation 2017 AIP ADVANCES ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1063/1.4994655
- Urzua, U; Chacon, C; Lizama, L; Sarmiento, S; Villalobos, P; Kroxato, B; Marcelain, K; Gonzalez, MJ Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice 2017 AGING AND DISEASE ISI;SCOPUS/UCH/VID http://dx.doi.org/10.14336/AD.2017.0110
- Signore, IA; Jerez, C; Figueroa, D; Suazo, J; Marcelain, K; Cerda, O; Flores, AC Inhibition of the 3-Hydroxy-3-Methyl-Glutaryl-CoA Reductase Induces Orofacial Defects in Zebrafish 2016 BIRTH DEFECTS RESEARCH PART A-CLINICAL AND MOLECULAR TERATOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/bdra.23546
- Bora B., Jain J., Inestrosa-Izurieta M.J., Avaria G., Moreno J., Pavez C., Marcelain K., Armisen R., Soto L. Development of plasma needle to be used for biomedical applications. 2016 Journal of Physics: Conference Series SCOPUS/UCH/VID http://dx.doi.org/10.1088/1742-6596/720/1/012038
- Jain J., Moreno J., Avaria G., Pavez C., Bora B., Inestrosa Izurieta M.J., Diez D., Alvarez O., Tapia J., Marcelain K., Armisen R., Soto L. Characterization of x-rays pulses from a hundred joules plasma focus to study its effects on cancer cells 2016 Journal of Physics: Conference Series SCOPUS/UCH/VID http://dx.doi.org/10.1088/1742-6596/720/1/012043
- Rivas, S; Armisen, R; Rojas, DA; Maldonado, E; Huerta, H; Tapia, JC; Espinoza, J; Colombo, A; Michea, L; Hayman, MJ; Marcelain, K. The Ski Protein is Involved in the Transformation Pathway of Aurora Kinase A 2016 JOURNAL OF CELLULAR BIOCHEMISTRY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/jcb.25275
- Bermejo, JL; Boekstegers, F; Silos, RG; Marcelain, K; Guajardo, MF; Rothhammer, F. Latino does not equal Latino: Major components of Native American Ancestry and Mortality due to Gallbladder Cancer in Chile. GENETIC EPIDEMIOLOGY ISI/UCH/VID
- Niechi, I;Silva, E;Cabello, P;Huerta, H;Carrasco, V;Villar, P;Cataldo, LR; Marcelain, K; Armisen, R;Varas-Godoy, M;Fernandez, C;Tapia, JC. Colon cancer cell invasion is promoted by protein kinase CK2 through increase of endothelin- converting enzyme-1c protein stability. 2015 ONCOTARGET ISI;SCOPUS/UCH/VID http://dx.doi.org/10.18632/oncotarget.5722
- Urzua, U; Chacon, C; Sarmiento, S; Lizama, L; Ampuero, S; Marcelain, K; Villalobos, P; Gonzalez, MJ; Romero, C. PARITY MODULATES THE OVARIAN TRANSCRIPTOME AND SYSTEMIC INFLAMMATORY MARKERS IN ESTROPAUSAL MICE. 2015 INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER ISI/UCH/VID
- Bermejo, JL; Silos, RG; Pell, B; Marcelain, K; Fuentes, M; Rothhammer, F Genetic Ancestry and Mortality in Chile 2015 HUMAN HEREDITY ISI/UCH/VID
- Cappelli, C; Urzua, U; Toro, J; Cassanova, E; Vargas, C; Donoso, G; Rivas, S; Orostica, K; Verdugo, R; Armisen, R; Marcelain, K. The transcriptional co-repressor Ski localizes in the pericentromeric region of mitotic chromosomes, regulating the expression of targeted genes at the early G1 phase of the cell cycle 2014 FEBS JOURNAL ISI/UCH/VID
- Sagredo, A;Sagredo, E;Salamanca, E;Luco, C;Andaur, R;Michea, L;Simon, F;Tapia, J;Marcelain, K;Armisen, R. The TRPM4 channel regulates the Epithelial-Mesenchymal transition in prostate cancer cells. FEBS JOURNAL ISI/UCH/VID
- Meruane, M.; Benítez, S.; Rojas, M.; Sagredo, A.; Marcelain, K.; Villalobos, B. Epitelización inducida por células troncales derivadas del tejido adiposo 2014 CIRUGIA PLASTICA IBERO-LATINOAMERICANA SCOPUS;SCIELO-otrospaises/UCH/VID http://dx.doi.org/10.4321/S0376-78922014000200001
- Colombo, A;Palma, K;Armijo, L;Mione, M;Signore, IA;Morales, C;Guerrero, N;Meynard, MM;Perez, R;Suazo, J;Marcelain, K;Briones, L;Haartel, S;Wilson, SW;Concha, ML. Daam1a mediates asymmetric habenular morphogenesis by regulating dendritic and axonal outgrowth 2013 DEVELOPMENT ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1242/dev.091934
- Arredondo, S; Aracena, M; Cares, C; Marcelain, K; Gonzalez-Hormazabal, P; Pincheira, J Heterogeneity of Immune Abnormalities in Children with Nijmegen Breakage Syndrome: Experience in a Single Center 2013 JOURNAL OF CLINICAL IMMUNOLOGY ISI/UCH/VID
- Marcelain, K;Armisen, R;Aguirre, A;Ueki, N;Toro, J;Colmenares, C;Hayman, MJ Chromosomal Instability in Mouse Embryonic Fibroblasts Null for the Transcriptional Co-Repressor Ski. 2012 JOURNAL OF CELLULAR PHYSIOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/jcp.22733
- Meruane, MA;Rojas, M;Marcelain, K. The Use of Adipose Tissue-Derived Stem Cells within a Dermal Substitute Improves Skin Regeneration by Increasing Neoangiogenesis and Collagen Synthesis. 2012 PLASTIC AND RECONSTRUCTIVE SURGERY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1097/PRS.0b013e3182547e04
- Armisen, R ; Marcelain, K ; Simon, F ; Tapia, JC ; Toro, J ; Quest, AFG ; Stutzin, A. TRPM4 Enhances Cell Proliferation Through Up-Regulation of the beta-Catenin Signaling Pathway. JOURNAL OF CELLULAR PHYSIOLOGY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/jcp.22310
- Mosquera, J ; Armisen, R ; Zhao, HL ; Rojas, DA ; Maldonado, E ; Tapia, JC ; Colombo, A ; Hayman, MJ ; Marcelain, K. Identification of Ski as a target for Aurora A kinase. 2011 BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1016/j.bbrc.2011.05.040
- Yefi, R;Ponce, DP;Niechi, I;Silva, E;Cabello, P;Rodriguez, DA; Marcelain, K; Armisen, R;Quest, AFG;Tapia, JC Protein Kinase CK2 Promotes Cancer Cell Viability Via Up-Regulation of Cyclooxygenase-2 Expression and Enhanced Prostaglandin E2 Production. JOURNAL OF CELLULAR BIOCHEMISTRY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1002/jcb.23247
- Ponce, DP; Yefi, R; Cabello, P; Maturana, JL; Niechi, I; Silva, E; Galindo, M; Antonelli, M; Marcelain, K; Armisen, R; Tapia, JC CK2 functionally interacts with AKT/PKB to promote the beta-catenin-dependent expression of survivin and enhance cell survival. MOLECULAR AND CELLULAR BIOCHEMISTRY ISI;SCOPUS/UCH/VID http://dx.doi.org/10.1007/s11010-011-0965-4
Memorias y Tesis
Inostroza Díaz, Victor Manuel. Papel de la proteína SKI y la vía TGF-ß en la mantención de la integridad genómica. Facultad de Medicina. 2016. Marcelain Cubillos, Katherine, Factor de crecimiento transformador beta. https://bibliotecadigital.uchile.cl/dis overy/fulldisplay?docid=alma99100293969703936&context=L&vid=56UDC_INST56UDC_INST&lang=es&search_scopeMyInst_and_CI
Vargas Romero, Cristóbal. Determinación de la expresión génica diferencial de 9 genes, entre células MEF que expresan y no expresan la proteína SKI. Facultad de Medicina. 2015. Marcelain, Katherine, Expresión del gen https://bibliotecadigital.uchile.cl/disovery/fulldisplay?docid=alma99100253409703936&context=L&vid=56UDC_INST56UDC_INST&lang=es&search_scopeMyInst_and_CI
Lineas de Investigación
– MECANISMOS EPIGENÉTICOS RELACIONADOS CON LA INESTABILIDAD GENÓMICA EN CÁNCER Y EN RESPUESTA A RADIACIONES IONIZANTES.
– ANÁLISIS DE MUTACIONES TUMORALES RELEVANTES PARA EL TRATAMIENTO DE TUMORES SÓLIDOS (MAMA, VESICULA BILIAR, GASTRICO, COLON, PULMON).
– GENÉTICA Y GENÓMICA DEL CÁNCER DE VESÍCULA BILIAR.
OTROS INTEGRANTES DEL DOBC
Dr. Enrique Castellon
Dr. Enrique Castellón Director Perfil Academico Publicaciones Proyectos
Dra. Katherine Marcelain
Dra. Katherine Marcelain. Perfil Academico Proyectos Publicaciones Memorias
Dra. Alicia Colombo
Dra. Alicia Colombo Consejera Departamento de Oncología Básico-Clínica