Laboratorio de Genómica Aplicada

LABORATORIO DEA GENÓMICA APLICADA

Estudios genómicos / transcriptómicos sobre iniciación y progresión del cáncer.
Interés particular: bases moleculares de la paridad como factor de disminución del riesgo en el cáncer de ovario.
El embarazo y el uso de anticonceptivos orales durante la edad fértil se han relacionado con un menor riesgo de esporádicos cáncer de ovario (OC) durante la postmenopausia.

Director DR. ULISES URZUA

Hemos utilizado ratones hembra C57BL6 endogámicos mantenidos en regímenes reproductivos divergentes (multíparos versus nulíparos) hasta el equivalente de estropapa-menopausia en mujeres- para estudiar la inducción tumoral y las citocinas circulantes1, acumulación de lipofuscina y hemosiderina, ADN daño oxidativo2 y los perfiles transcriptómicos dependientes de la paridad de ovarios envejecidos3. Anteriormente, nosotros caracterizó los perfiles de número de copia de transcriptoma y ADN de todo el genoma durante la transformación in vitro de células de superficie ovárica de ratón (MOSE) 4, un candidato de capa celular para ser un precursor OC.

Equipo Científico

Dr. Ulises Urzua

Dr. Ulises Urzua Consejero Departamento de Oncología Básico

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PUBLICACIONES

PROYECTOS DE INVESTIGACIÓN

MEMORIAS Y TESIS

PUBLICACIONES

Autores	Título publicación	Año	Título revista	Tipo publicación	Digital object identifier
Cortes, J; Hidalgo, J; Aguilera, S; Castro, I; Brito, M; Urra, H; Perez, P; Barrera, MJ; Carvajal, P; Urzua, U; Gonzalez, S; Molina, C; Bahamondes, V; Hermoso, M; Gonzalez, MJ	Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren’s syndrome patients	2019	JOURNAL OF AUTOIMMUNITY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jaut.2018.10.019
Calaf G.M., Urzua U., Termini L., Aguayo F.	Oxidative stress in female cancers	2018	ONCOTARGET	SCOPUS/UCH/VID	http://dx.doi.org/10.18632/oncotarget.25323
Barrera, MJ; Aguilera, S; Castro, I; Carvajal, P; Gonzalez, S; Molina, C; Urzua, U; Gonzalez, MJ	Expression of JAK Proteins and Autophagy Markers in Sjogren’s Syndrome Patients	2018	ARTHRITIS & RHEUMATOLOGY	ISI/UCH/VID
Castro, I; Brockhausen, I; Aguilera, S; Barrera, MJ; Gonzalez, S; Molina, C; Urzua, U; Leyton, C; Gonzalez, MJ	The levels, subcellular distribution and posttranslational processing of salivary mucins are affected	2018	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY	ISI/UCH/VID
Ampuero, S; Andaur, R; Milano, M; Moreno, M; Lizama, L; Larranaga, C; Urzua, U	Time-course of transcriptome response to respiratory syncytial virus infection in lung epithelium cells	2018	ACTA VIROLOGICA	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.4149/av_2018_225
Barrera, MJ; Aguilera, S; Bahamondes, V; Sepulveda, D; Castro, I; Matus, S; Carvajal, P; Gonzalez, S; Molina, C; Urzua, U; Gonzalez, MJ	Are unfolded protein response pathways modulated by inflammation in salivary glands of Sjogren’s syndrome patients?	2018	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY	ISI/UCH/VID
Urzua, U; Chacon, C; Espinoza, R; Martinez, S; Hernandez, N	Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary	2018	ANALYTICAL CELLULAR PATHOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1155/2018/1289103
Lagos, C; Caryajal, P; Castro, I; Jara, D; Gonzalez, S; Aguilera, S; Barrera, MJ; Quest, AFG; Bahamondes, V; Molina, C; Urzua, U; Hermoso, MA; Leyton, C; Gonzalez, MJ	Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren’s syndrome patients	2018	CLINICAL IMMUNOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.clim.2018.06.002
Sepulveda, D; Barrera, MJ; Castro, I; Aguilera, S; Carvajal, P; Lagos, C; Gonzalez, S; Albornoz, N; Bahamondes, V; Quest, AFG; Urzua, U; Molina, C; Leyton, C; Hermoso, MA; Gonzalez, MJ	Impaired IRE1a/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients	2018	RHEUMATOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1093/rheumatology/key021
Gonzalez, S; Albornoz, N; Barrera, MJ; Aguilera, S; Castro, I; Urzua, U; Biunno, I; Petruscu, S; Gonzalez, MJ	TUDCA reduces inflammatory markers in salivary gland cells decreasing MUC1 accumulation. A potential therapeutic agent to ameliorate inflammation in Sjogren’s syndrome	2018	CLINICAL AND EXPERIMENTAL RHEUMATOLOGY	ISI/UCH/VID
Castro I., Barrera M.-J., González S., Aguilera S., Urzúa U., Cortés J., González M.-J.	Mucins in salivary gland development, regeneration, and disease	2017	Salivary Gland Development and Regeneration: Advances in Research and Clinical Approaches to Functional Restoration	SCOPUS/UCH/VID	http://dx.doi.org/10.1007/978-3-319-43513-8_3
Urzua, U; Chacon, C; Lizama, L; Sarmiento, S; Villalobos, P; Kroxato, B; Marcelain, K; Gonzalez, MJ	Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice	2017	AGING AND DISEASE	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.14336/AD.2017.0110
Carrillo, D; Munoz, JP; Huerta, H; Leal, G; Corvalan, A; Leon, O; Calaf, GM; Urzua, U; Boccardo, E; Tapia, JC; Aguayo, F	Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells	2017	OPEN BIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1098/rsob.170111
Urzua, U; Ampuero, S; Roby, KF; Owens, GA; Munroe, DJ	Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells	2016	BMC GENOMICS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1186/s12864-016-3068-5
Barrera, MJ; Aguilera, S; Castro, I; Cortes, J; Bahamondes, V; Quest, AFG; Molina, C; Gonzalez, S; Hermoso, M; Urzua, U; Leyton, C; Gonzalez, MJ	Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren’s syndrome patients	2016	JOURNAL OF AUTOIMMUNITY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jaut.2016.07.006
Barrera, MJ; Aguilera, S; Castro, I; Cortes, J; Bahamondes, V; Urzua, U; Gonzalez, S; Molina, C; Leyton, C; Gonzalez, MJ	ROLE OF PRO-INFLAMMATORY CYTOKINES IN THE ENDOPLASMIC RETICULUM ASSOCIATED-PROTEIN DEGRADATION IN SJOGREN’S SYNDROME PATIENTS	2016	ANNALS OF THE RHEUMATIC DISEASES	ISI/UCH/VID	http://dx.doi.org/10.1136/annrheumdis-2016-eular.1841
Bahamondes, V; Aguilera, S; Cortes, J; Castro, I; Barrera, MJ; Urzua, U; Gonzalez, S; Molina, C; Leyton, C; Gonzalez, MJ	PERK PATHWAY CHARACTERIZATION IN LABIAL SALIVARY GLANDS OF SJOGREN SYNDROME’S PATIENTS: COULD IT BE AN ADAPTIVE RESPONSE?	2016	ANNALS OF THE RHEUMATIC DISEASES	ISI/UCH/VID	http://dx.doi.org/10.1136/annrheumdis-2016-eular.1832
Barrera, MJ; Aguilera, S; Veerman, E; Quest, AFG; Diaz-Jimenez, D; Urzua, U; Cortes, J; Gonzalez, S; Castro, I; Molina, C; Bahamondes, V; Leyton, C; Hermoso, MA; Gonzalez, MJ	Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren’s syndrome?	2015	RHEUMATOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1093/rheumatology/kev026
Adonis, M; Tamayo, C; Urzua, U; Chahuan, M; Miranda, VR; Campos, M; Zambrano, A; Benitez, H; Marin, P; Gil, L	cfDNA in Lung Cancer Patients and People with High Risk of LC Exposed to Environmental Pollution	2015	JOURNAL OF THORACIC ONCOLOGY	ISI/UCH/VID
Pena, N; Carrillo, D; Munoz, JP; Chnaiderman, J; Urzua, U; Leon, O; Tornesello, ML; Corvalan, AH; Soto-Rifo, R; Aguayo, F	Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells	2015	PLOS ONE	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1371/journal.pone.0123029
Urzua, U; Chacon, C; Sarmiento, S; Lizama, L; Ampuero, S; Marcelain, K; Villalobos, P; Gonzalez, MJ; Romero, C	PARITY MODULATES THE OVARIAN TRANSCRIPTOME AND SYSTEMIC INFLAMMATORY MARKERS IN ESTROPAUSAL MICE	2015	INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER	ISI/UCH/VID
Sung, HH; Castro, I; Gonzalez, S; Aguilera, S; Smorodinsky, NI; Quest, AFG; Bahamondes, V; Alliende, C; Cortes, J; Molina, C; Urzua, U; Barrera, MJ; Hermoso, M; Herrera, L; Leyton, C; Gonzalez, MJ	MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren’s syndrome	2015	ORAL DISEASES	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1111/odi.12339
Aquea, G;Bresky, G;Lancellotti, D;Madariaga, JA;Zaffiri, V;Urzua, U;Haberle, S;Bernal, G	Increased Expression of P2RY2, CD248 and EphB1 in Gastric Cancers from Chilean Patients	2014	ASIAN PACIFIC JOURNAL OF CANCER PREVENTION	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.7314/APJCP.2014.15.5.1931
Fernandez, JG;Rodriguez, DA;Valenzuela, M;Calderon, C;Urzua, U;Munroe, D;Rosas, C;Lemus, D;Diaz, N;Wright, MC;Leyton, L;Tapia, JC;Quest, AFG	Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription	2014	MOLECULAR CANCER	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1186/1476-4598-13-209
Adonis, MI;Diaz, J;Miranda, VR;Chahuan, M;Zambrano, A;Benitez, HC;Campos, M;Avaria, P;Urzua, U;Marin, P;Gohurdett, M;Cisterna, Y;Gil, L	Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population	2014	BIOLOGICAL RESEARCH	ISI;SCIELO-Chile/UCH/VID	http://dx.doi.org/10.1186/0717-6287-47-62
Molina-Quiroz, RC;Loyola, DE;Daiz-Vasquez, WA;Arenas, FA;Urzua, U;Perez-Donoso, JM;Vasquez, CC	Global transcriptomic analysis uncovers a switch to anaerobic metabolism in tellurite-exposed Escherichia coli	2014	RESEARCH IN MICROBIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.resmic.2014.07.003
Cappelli, C;Urzua, U;Toro, J;Cassanova, E;Vargas, C;Donoso, G;Rivas, S;Orostica, K;Verdugo, R;Armisen, R;Marcelain, K	The transcriptional co-repressor Ski localizes in the pericentromeric region of mitotic chromosomes, regulating the expression of targeted genes at the early G1 phase of the cell cycle	2014	FEBS JOURNAL	ISI/UCH/VID
Tamayo, CA;Urzua, U;Chahuan, M;Miranda, R;Campos, M;Zambrano, A;Benitez, H;Marin, P;Gil, L;Adonis, M	FREE CIRCULATING DNA LEVELS IN INDIVIDUALS WITH LUNG CANCER RISK AND CHARACTERIZATION OF COPY NUMBER ALTERATIONS.	2014	JOURNAL OF THORACIC ONCOLOGY	ISI/UCH/VID
Adonis, M;Urzua, U;Contreras, L;Tamayo, C;Lorca, L;Chahuan, M;Miranda, V;Campos, M;Benitez, H;Zambrano, A;Marin, P;Gil, L	GENOMIC ALTERATION IN SPUTUM SAMPLES AND DNAFC OF LUNG CANCER HIGH RISK CHILEAN POPULATION	2013	JOURNAL OF THORACIC ONCOLOGY	ISI/UCH/VID	http://dx.doi.org/10.1097/01.JTO.0000438438.14562.c8
Castro, I;Sepulveda, D;Cortes, J;Quest, AFG;Barrera, MJ;Bahamondes, V;Aguilera, S;Urzua, U;Alliende, C;Molina, C;Gonzalez, S;Hermoso, MA;Leyton, C;Gonzalez, MJ	Oral dryness in Sjogren’s syndrome patients. Not just a question of water	2013	AUTOIMMUNITY REVIEWS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.autrev.2012.10.018
Barrera, MJ;Bahamondes, V;Sepulveda, D;Quest, AFG;Castro, I;Cortes, J;Aguilera, S;Urzua, U;Molina, C;Perez, P;Ewert, P;Alliende, C;Hermoso, MA;Gonzalez, S;Leyton, C;Gonzalez, MJ	Sjogren’s syndrome and the epithelial target: A comprehensive review	2013	JOURNAL OF AUTOIMMUNITY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jaut.2013.02.001
Gonzalez, S;Aguilera, S;Urzua, U;Quest, AFG;Molina, C;Alliende, C;Hermoso, M;Gonzalez, MJ	Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011)	2012	AUTOIMMUNITY REVIEWS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.autrev.2011.04.008
Adonis, M;Diaz, J;Miranda, R;Chahuan, M;Zambrano, A;Campos, M;Benitez, H;Avaria, P;Urzua, U;Cisterna, Y;Contreras, L;Marin, P;Lam, S;Gil, L	BIOLOGICAL BIOMARKERS FOR SCREENING OF PRE NEOPLASTIC LESIONS ASSOCIATED TO LUNG CANCER IN A RISK CHILEAN POPULATION	2012	JOURNAL OF THORACIC ONCOLOGY	ISI/UCH/VID	http://dx.doi.org/10.1097/JTO.0b013e318262df76
Contreras, A;Garcia, V;Salinas, F;Urzua, U;Ganga, MA;Martinez, C	Identification of genes related to nitrogen uptake in wine strains of Saccharomyces cerevisiae	2012	WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1007/s11274-011-0911-3
Castro, I;Aguilera, S;Brockhausen, I;Alliende, C;Quest, AFG;Molina, C;Urzua, U;Mandel, U;Bahamondes, V;Barrera, MJ;Sanchez, M;Gonzalez, S;Hermoso, M;Leyton, C;Gonzalez, MJ	Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren’s syndrome patients	2012	RHEUMATOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1093/rheumatology/ker351
Barrera, MJ;Sanchez, M;Aguilera, S;Alliende, C;Bahamondes, V;Molina, C;Quest, AFG;Urzua, U;Castro, I;Gonzalez, S;Sung, HH;Albornoz, A;Hermoso, M;Leyton, C;Gonzalez, MJ	Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren’s syndrome patients is linked to ectopic mucin secretion	2012	JOURNAL OF AUTOIMMUNITY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jaut.2012.01.011
Sanchez, M;Aguilera, S;Barrera, MJ;Alliende, C;Bahamondes, V;Castro, I;Gonzalez, S;Molina, C;Leyton, C;Urzua, U;Sung, HH;Gonzalez, MJ	ALTERATIONS OF VAMP2 AND SINTAXIN-2 IN SALIVARY ACINAR CELLS MODIFY THE SECRETION PROCESS IN SJOGREN’S SYNDROME PATIENTS	2012	ANNALS OF THE RHEUMATIC DISEASES	ISI/UCH/VID
Urzua, U;Tapia, V;Geraldo, MP;Selman, A;Vega, M;Romero, C	Nerve Growth Factor Stimulates Cellular Proliferation of Human Epithelial Ovarian Cancer	2012	HORMONE AND METABOLIC RESEARCH	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1055/s-0032-1304617
Gonzalez, S ; Aguilera, S ; Urzua, U ; Quest, AFG ; Molina, C ; Alliende, C ; Hermoso, M ; Gonzalez, MJ	Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011)	2011	AUTOIMMUNITY REVIEWS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.autrev.2011.03.002
Mattison, K ; Corneau, N ; Berg, I ; Bosch, A ; Duizer, E ; Gutierrez-Aguirre, I ; L’Homme, Y ; Lucero, Y ; Luo, ZY ; Martyres, A ; Myrmel, M ; O’Ryan, M ; Pagotto, F ; Sano, D ; Svraka, S ; Urzua, U ; Bidawid, S	Development and validation of a microarray for the confirmation and typing of norovirus RT-PCR products	2011	JOURNAL OF VIROLOGICAL METHODS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jviromet.2011.02.011
Gonzalez, S ; Aguilera, S ; Alliende, C ; Urzua, U ; Quest, AFG ; Herrera, L ; Molina, C ; Hermoso, M ; Ewert, P ; Brito, M ; Romo, R ; Leyton, C ; Perez, P ; Gonzalez, MJ	Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren’s Syndrome	2011	ARTHRITIS AND RHEUMATISM	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1002/art.30212
Bahamondes, V ; Albornoz, A ; Aguilera, S ; Alliende, C ; Molina, C ; Castro, I ; Urzua, U ; Quest, AFG ; Barrera, MJ ; Gonzalez, S ; Sanchez, M ; Hartel, S ; Hermoso, M ; Leyton, C ; Gonzalez, MJ	Changes in Rab3D Expression and Distribution in the Acini of Sjogren’s Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction	2011	ARTHRITIS AND RHEUMATISM	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1002/art.30500
Gonzalez, S ; Aguilera, S ; Urzua, U ; Quest, AFG ; Molina, C ; Alliende, C ; Hermoso, M ; Gonzalez, MJ	Mechanotransduction and epigenetic control in autoimmune diseases	2011	AUTOIMMUNITY REVIEWS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.autrev.2010.09.022
Ewert, P ; Aguilera, S ; Alliende, C ; Kwon, YJ ; Albornoz, A ; Molina, C ; Urzua, U ; Quest, AFG ; Olea, N ; Perez, P ; Castro, I ; Barrera, MJ ; Romo, R ; Hermoso, M ; Leyton, C ; Gonzalez, MJ	Disruption of Tight Junction Structure in Salivary Glands From Sjogren’s Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure	2010	ARTHRITIS AND RHEUMATISM	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1002/art.27362
Urzua, U ; Best, L ; Munroe, DJ	Microarray proteomic analysis discriminates tumorigenic mouse ovarian surface epithelial cells of divergent aggressive potential	2010	MOLECULAR BIOSYSTEMS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1039/c005220e
Maldonado, V ; Espinosa, M ; Pruefer, F ; Patino, N ; Ceballos-Cancino, G ; Urzua, U ; Juretic, N ; Melendez-Zajgla, J	Gene Regulation by BCL3 in a Cervical Cancer Cell Line	2010	FOLIA BIOLOGICA	ISI;SCOPUS/UCH/VID
Urzua, U ; Owens, GA ; Zhang, GM ; Cherry, JM ; Sharp, JJ ; Munroe, DJ	Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis	2010	BMC GENOMICS	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1186/1471-2164-11-S5-S1
Salinas, F ; Mandakovic, D ; Urzua, U ; Massera, A ; Miras, S ; Combina, M ; Ganga, MA ; Martinez, C	Genomic and phenotypic comparison between similar wine yeast strains of Saccharomyces cerevisiae from different geographic origins	2010	JOURNAL OF APPLIED MICROBIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1111/j.1365-2672.2010.04689.x
Perez, P; Anaya, JM; Aguilera, S; Urzua, U; Munroe, D; Molina, C; Hermoso, MA; Cherry, JM; Alliende, C; Olea, N; Ruiz-Narvaez, E; Gonzalez, MJ	Gene expression and chromosomal location for susceptibility to Sjogren’s syndrome	2009	JOURNAL OF AUTOIMMUNITY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1016/j.jaut.2009.05.001
Juretic, N ; Urzua, U ; Munroe, DJ ; Jaimovich, E ; Riveros, N	Differential gene expression in skeletal muscle cells after membrane depolarization	2007	JOURNAL OF CELLULAR PHYSIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1002/jcp.20902
Urzua, U; Roby, KF; Gangi, LM; Cherry, JM; Powell, JI; Munroe, DJ	Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets	2006	JOURNAL OF CELLULAR PHYSIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1002/jcp.20522
Frankenberger C; Wu X; Harmon J; Church D; Gangi L.M; Munroe D.J; Urzua U.	WebaCGH: An interactive online tool for the analysis and display of array comparative genomic hybridisation data	2006	Applied Bioinformatics	SCOPUS/UCH/VID	http://dx.doi.org/10.2165/00822942-200605020-00009
Perez, P; Urzua, U; Munroe, D; Aguilera, S; Kwon, Y; Molina, C; Alliende, C; Leyton, C; Gonzalez, M	Transcriptional profile of the salivary gland epithelium in Sjogren’s syndrome patients	2005	ANNALS OF THE RHEUMATIC DISEASES	ISI/UCH/VID
Urzua, U; Frankenberger, C; Gangi, L; Mayer, S; Burkett, S; Munroe, DJ	Microarray comparative genomic hybridization profile of a murine model for epithelial ovarian cancer reveals genomic imbalances resembling human ovarian carcinomas	2005	TUMOR BIOLOGY	ISI;SCOPUS/UCH/VID	http://dx.doi.org/10.1159/000087378

PROYECTOS DE INVESTIGACIÓN

Código proyecto	Título proyecto	Inicio	Fin	Investigador principal / Coinvestigadores	Institución / Unidad académica principal	Programa	Fuente
1130292	Ovarian cancer initiation and spread in a syngeneic mouse model at estropausal state	01-03-2013	01-03-2016	U. Urzua / C. Romero; M. GONZÁLEZ	UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular	FONDECYT	Regular
1120222	Ski-containing transciptional co-repressor complexes on mitotic chromosomes repress the expression of selected target genes at early G1	01-03-2012	01-03-2015	K. Marcelain / R. Armisen; U. Urzua	UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana	FONDECYT	Regular
1100477	Biomarkers for identification Chilean infants at risk for respiratory suncytial virus (RSV) and rhinovirus (RV)- induced severe acute lower respiratory infection	01-03-2010	01-03-2013	C. Larrañaga / A. Gaggero; L. Tapia; M. Palomino; S. Ampuero; U. Urzua; V. Luchsinger	UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Virología	FONDECYT	Regular
07CN13PBT-48	Prevención y detección temprana de cáncer pulmonar con base en genómica e imageneología de punta	01-12-2007	01-12-2010	D. Gil / A. Quest; A. Undurraga; C. Del Castillo; M. Adonis; N. Juretic; U. Urzua; V. Martinez	UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular	INNOVA	Innova-interés público y precompetitivo
I2 05/09-2	Detección de alteraciones transcripcionales y genómicas en cáncer ovárico epitelial de diferentes estadios mediante tecnología de microarreglos de DNA	01-07-2005	01-07-2007	U. Urzua / C. Romero; M. GONZÁLEZ	UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular	Fondo Central de Investigación	INICIACION

MEMORIAS Y TESIS

Autor(es)	Título	Facultad	Año publicación	Profesor(es) guía	Comisión	Tema	Url	Fuente
Núñez Araos, Francisco Javier	Patrón de expresión de los genes eotaxina 2, Mip 1a, TLR-3, IRF-3 e IRF-7, en la co-infección por virus respiratorio sincicial y rhinovirus en células pulmonares NCI-H292	Facultad de Medicina	2016	Ampuero Llanos, Sandra,;Urzúa Tobar, Ulises,		Infecciones por virus sincitial respiratorio;Genética;Infecciones por picornaviridae;Genética;Infecciones respiratorias;Genética;Coinfección células epiteliales;Virología;Quimiocina CCL24	https://bibliotecadigital.uchile.cl/pri o-explore/fulldisplay?docid=uchile_alma 1120492520003936&context=L&vid= 6UDC_INST&search_scope=uchile_scope amp;tab=uchile_tab&lang=es_CL	B Digital
Núñez Araos, Francisco Javier	Patrón de expresión de los genes eotaxina 2, Mip 1a, TLR-3, IRF-3 e IRF-7, en la co-infección por virus respiratorio sincicial y rhinovirus en células pulmonares NCI-H292 /	Facultad de Medicina	2016	Ampuero Llanos, Sandra,;Urzúa Tobar, Ulises,		Infecciones por virus sincitial respiratorio;Genética.;INFECCIONES POR PICORNAVIRIDAE;Genética.;Infecciones respiratorias;Genética.;Coinfección células epiteliales;Virología;Quimiocina CCL24	https://bibliotecadigital.uchile.cl/pri o-explore/fulldisplay?docid=uchile_alma 1120492520003936&context=L&vid= 6UDC_INST&search_scope=uchile_scope amp;tab=uchile_tab&lang=es_CL	B Digital

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