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Estudios genómicos / transcriptómicos sobre iniciación y progresión del cáncer.
Interés particular: bases moleculares de la paridad como factor de disminución del riesgo en el cáncer de ovario.
El embarazo y el uso de anticonceptivos orales durante la edad fértil se han relacionado con un menor riesgo de esporádicos cáncer de ovario (OC) durante la postmenopausia.
Hemos utilizado ratones hembra C57BL6 endogámicos mantenidos en regímenes reproductivos divergentes (multíparos versus nulíparos) hasta el equivalente de estropapa-menopausia en mujeres- para estudiar la inducción tumoral y las citocinas circulantes1, acumulación de lipofuscina y hemosiderina, ADN daño oxidativo2 y los perfiles transcriptómicos dependientes de la paridad de ovarios envejecidos3. Anteriormente, nosotros caracterizó los perfiles de número de copia de transcriptoma y ADN de todo el genoma durante la transformación in vitro de células de superficie ovárica de ratón (MOSE) 4, un candidato de capa celular para ser un precursor OC.
Autores | Título publicación | Año | Título revista | Tipo publicación | Digital object identifier |
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Cortes, J; Hidalgo, J; Aguilera, S; Castro, I; Brito, M; Urra, H; Perez, P; Barrera, MJ; Carvajal, P; Urzua, U; Gonzalez, S; Molina, C; Bahamondes, V; Hermoso, M; Gonzalez, MJ | Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjogren’s syndrome patients | 2019 | JOURNAL OF AUTOIMMUNITY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jaut.2018.10.019 |
Calaf G.M., Urzua U., Termini L., Aguayo F. | Oxidative stress in female cancers | 2018 | ONCOTARGET | SCOPUS/UCH/VID | http://dx.doi.org/10.18632/oncotarget.25323 |
Barrera, MJ; Aguilera, S; Castro, I; Carvajal, P; Gonzalez, S; Molina, C; Urzua, U; Gonzalez, MJ | Expression of JAK Proteins and Autophagy Markers in Sjogren’s Syndrome Patients | 2018 | ARTHRITIS & RHEUMATOLOGY | ISI/UCH/VID | |
Castro, I; Brockhausen, I; Aguilera, S; Barrera, MJ; Gonzalez, S; Molina, C; Urzua, U; Leyton, C; Gonzalez, MJ | The levels, subcellular distribution and posttranslational processing of salivary mucins are affected | 2018 | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | ISI/UCH/VID | |
Ampuero, S; Andaur, R; Milano, M; Moreno, M; Lizama, L; Larranaga, C; Urzua, U | Time-course of transcriptome response to respiratory syncytial virus infection in lung epithelium cells | 2018 | ACTA VIROLOGICA | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.4149/av_2018_225 |
Barrera, MJ; Aguilera, S; Bahamondes, V; Sepulveda, D; Castro, I; Matus, S; Carvajal, P; Gonzalez, S; Molina, C; Urzua, U; Gonzalez, MJ | Are unfolded protein response pathways modulated by inflammation in salivary glands of Sjogren’s syndrome patients? | 2018 | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | ISI/UCH/VID | |
Urzua, U; Chacon, C; Espinoza, R; Martinez, S; Hernandez, N | Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary | 2018 | ANALYTICAL CELLULAR PATHOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1155/2018/1289103 |
Lagos, C; Caryajal, P; Castro, I; Jara, D; Gonzalez, S; Aguilera, S; Barrera, MJ; Quest, AFG; Bahamondes, V; Molina, C; Urzua, U; Hermoso, MA; Leyton, C; Gonzalez, MJ | Association of high 5-hydroxymethylcytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren’s syndrome patients | 2018 | CLINICAL IMMUNOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.clim.2018.06.002 |
Sepulveda, D; Barrera, MJ; Castro, I; Aguilera, S; Carvajal, P; Lagos, C; Gonzalez, S; Albornoz, N; Bahamondes, V; Quest, AFG; Urzua, U; Molina, C; Leyton, C; Hermoso, MA; Gonzalez, MJ | Impaired IRE1a/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren’s syndrome patients | 2018 | RHEUMATOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1093/rheumatology/key021 |
Gonzalez, S; Albornoz, N; Barrera, MJ; Aguilera, S; Castro, I; Urzua, U; Biunno, I; Petruscu, S; Gonzalez, MJ | TUDCA reduces inflammatory markers in salivary gland cells decreasing MUC1 accumulation. A potential therapeutic agent to ameliorate inflammation in Sjogren’s syndrome | 2018 | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | ISI/UCH/VID | |
Castro I., Barrera M.-J., González S., Aguilera S., Urzúa U., Cortés J., González M.-J. | Mucins in salivary gland development, regeneration, and disease | 2017 | Salivary Gland Development and Regeneration: Advances in Research and Clinical Approaches to Functional Restoration | SCOPUS/UCH/VID | http://dx.doi.org/10.1007/978-3-319-43513-8_3 |
Urzua, U; Chacon, C; Lizama, L; Sarmiento, S; Villalobos, P; Kroxato, B; Marcelain, K; Gonzalez, MJ | Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice | 2017 | AGING AND DISEASE | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.14336/AD.2017.0110 |
Carrillo, D; Munoz, JP; Huerta, H; Leal, G; Corvalan, A; Leon, O; Calaf, GM; Urzua, U; Boccardo, E; Tapia, JC; Aguayo, F | Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells | 2017 | OPEN BIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1098/rsob.170111 |
Urzua, U; Ampuero, S; Roby, KF; Owens, GA; Munroe, DJ | Dysregulation of mitotic machinery genes precedes genome instability during spontaneous pre-malignant transformation of mouse ovarian surface epithelial cells | 2016 | BMC GENOMICS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1186/s12864-016-3068-5 |
Barrera, MJ; Aguilera, S; Castro, I; Cortes, J; Bahamondes, V; Quest, AFG; Molina, C; Gonzalez, S; Hermoso, M; Urzua, U; Leyton, C; Gonzalez, MJ | Pro-inflammatory cytokines enhance ERAD and ATF6 alpha pathway activity in salivary glands of Sjogren’s syndrome patients | 2016 | JOURNAL OF AUTOIMMUNITY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jaut.2016.07.006 |
Barrera, MJ; Aguilera, S; Castro, I; Cortes, J; Bahamondes, V; Urzua, U; Gonzalez, S; Molina, C; Leyton, C; Gonzalez, MJ | ROLE OF PRO-INFLAMMATORY CYTOKINES IN THE ENDOPLASMIC RETICULUM ASSOCIATED-PROTEIN DEGRADATION IN SJOGREN’S SYNDROME PATIENTS | 2016 | ANNALS OF THE RHEUMATIC DISEASES | ISI/UCH/VID | http://dx.doi.org/10.1136/annrheumdis-2016-eular.1841 |
Bahamondes, V; Aguilera, S; Cortes, J; Castro, I; Barrera, MJ; Urzua, U; Gonzalez, S; Molina, C; Leyton, C; Gonzalez, MJ | PERK PATHWAY CHARACTERIZATION IN LABIAL SALIVARY GLANDS OF SJOGREN SYNDROME’S PATIENTS: COULD IT BE AN ADAPTIVE RESPONSE? | 2016 | ANNALS OF THE RHEUMATIC DISEASES | ISI/UCH/VID | http://dx.doi.org/10.1136/annrheumdis-2016-eular.1832 |
Barrera, MJ; Aguilera, S; Veerman, E; Quest, AFG; Diaz-Jimenez, D; Urzua, U; Cortes, J; Gonzalez, S; Castro, I; Molina, C; Bahamondes, V; Leyton, C; Hermoso, MA; Gonzalez, MJ | Salivary mucins induce a Toll-like receptor 4-mediated pro-inflammatory response in human submandibular salivary cells: are mucins involved in Sjogren’s syndrome? | 2015 | RHEUMATOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1093/rheumatology/kev026 |
Adonis, M; Tamayo, C; Urzua, U; Chahuan, M; Miranda, VR; Campos, M; Zambrano, A; Benitez, H; Marin, P; Gil, L | cfDNA in Lung Cancer Patients and People with High Risk of LC Exposed to Environmental Pollution | 2015 | JOURNAL OF THORACIC ONCOLOGY | ISI/UCH/VID | |
Pena, N; Carrillo, D; Munoz, JP; Chnaiderman, J; Urzua, U; Leon, O; Tornesello, ML; Corvalan, AH; Soto-Rifo, R; Aguayo, F | Tobacco Smoke Activates Human Papillomavirus 16 p97 Promoter and Cooperates with High-Risk E6/E7 for Oxidative DNA Damage in Lung Cells | 2015 | PLOS ONE | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1371/journal.pone.0123029 |
Urzua, U; Chacon, C; Sarmiento, S; Lizama, L; Ampuero, S; Marcelain, K; Villalobos, P; Gonzalez, MJ; Romero, C | PARITY MODULATES THE OVARIAN TRANSCRIPTOME AND SYSTEMIC INFLAMMATORY MARKERS IN ESTROPAUSAL MICE | 2015 | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | ISI/UCH/VID | |
Sung, HH; Castro, I; Gonzalez, S; Aguilera, S; Smorodinsky, NI; Quest, AFG; Bahamondes, V; Alliende, C; Cortes, J; Molina, C; Urzua, U; Barrera, MJ; Hermoso, M; Herrera, L; Leyton, C; Gonzalez, MJ | MUC1/SEC and MUC1/Y overexpression is associated with inflammation in Sjogren’s syndrome | 2015 | ORAL DISEASES | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1111/odi.12339 |
Aquea, G;Bresky, G;Lancellotti, D;Madariaga, JA;Zaffiri, V;Urzua, U;Haberle, S;Bernal, G | Increased Expression of P2RY2, CD248 and EphB1 in Gastric Cancers from Chilean Patients | 2014 | ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.7314/APJCP.2014.15.5.1931 |
Fernandez, JG;Rodriguez, DA;Valenzuela, M;Calderon, C;Urzua, U;Munroe, D;Rosas, C;Lemus, D;Diaz, N;Wright, MC;Leyton, L;Tapia, JC;Quest, AFG | Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced beta-catenin/Tcf-Lef dependent transcription | 2014 | MOLECULAR CANCER | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1186/1476-4598-13-209 |
Adonis, MI;Diaz, J;Miranda, VR;Chahuan, M;Zambrano, A;Benitez, HC;Campos, M;Avaria, P;Urzua, U;Marin, P;Gohurdett, M;Cisterna, Y;Gil, L | Biomarkers for screening of lung cancer and pre-neoplastic lesions in a high risk Chilean population | 2014 | BIOLOGICAL RESEARCH | ISI;SCIELO-Chile/UCH/VID | http://dx.doi.org/10.1186/0717-6287-47-62 |
Molina-Quiroz, RC;Loyola, DE;Daiz-Vasquez, WA;Arenas, FA;Urzua, U;Perez-Donoso, JM;Vasquez, CC | Global transcriptomic analysis uncovers a switch to anaerobic metabolism in tellurite-exposed Escherichia coli | 2014 | RESEARCH IN MICROBIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.resmic.2014.07.003 |
Cappelli, C;Urzua, U;Toro, J;Cassanova, E;Vargas, C;Donoso, G;Rivas, S;Orostica, K;Verdugo, R;Armisen, R;Marcelain, K | The transcriptional co-repressor Ski localizes in the pericentromeric region of mitotic chromosomes, regulating the expression of targeted genes at the early G1 phase of the cell cycle | 2014 | FEBS JOURNAL | ISI/UCH/VID | |
Tamayo, CA;Urzua, U;Chahuan, M;Miranda, R;Campos, M;Zambrano, A;Benitez, H;Marin, P;Gil, L;Adonis, M | FREE CIRCULATING DNA LEVELS IN INDIVIDUALS WITH LUNG CANCER RISK AND CHARACTERIZATION OF COPY NUMBER ALTERATIONS. | 2014 | JOURNAL OF THORACIC ONCOLOGY | ISI/UCH/VID | |
Adonis, M;Urzua, U;Contreras, L;Tamayo, C;Lorca, L;Chahuan, M;Miranda, V;Campos, M;Benitez, H;Zambrano, A;Marin, P;Gil, L | GENOMIC ALTERATION IN SPUTUM SAMPLES AND DNAFC OF LUNG CANCER HIGH RISK CHILEAN POPULATION | 2013 | JOURNAL OF THORACIC ONCOLOGY | ISI/UCH/VID | http://dx.doi.org/10.1097/01.JTO.0000438438.14562.c8 |
Castro, I;Sepulveda, D;Cortes, J;Quest, AFG;Barrera, MJ;Bahamondes, V;Aguilera, S;Urzua, U;Alliende, C;Molina, C;Gonzalez, S;Hermoso, MA;Leyton, C;Gonzalez, MJ | Oral dryness in Sjogren’s syndrome patients. Not just a question of water | 2013 | AUTOIMMUNITY REVIEWS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.autrev.2012.10.018 |
Barrera, MJ;Bahamondes, V;Sepulveda, D;Quest, AFG;Castro, I;Cortes, J;Aguilera, S;Urzua, U;Molina, C;Perez, P;Ewert, P;Alliende, C;Hermoso, MA;Gonzalez, S;Leyton, C;Gonzalez, MJ | Sjogren’s syndrome and the epithelial target: A comprehensive review | 2013 | JOURNAL OF AUTOIMMUNITY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jaut.2013.02.001 |
Gonzalez, S;Aguilera, S;Urzua, U;Quest, AFG;Molina, C;Alliende, C;Hermoso, M;Gonzalez, MJ | Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011) | 2012 | AUTOIMMUNITY REVIEWS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.autrev.2011.04.008 |
Adonis, M;Diaz, J;Miranda, R;Chahuan, M;Zambrano, A;Campos, M;Benitez, H;Avaria, P;Urzua, U;Cisterna, Y;Contreras, L;Marin, P;Lam, S;Gil, L | BIOLOGICAL BIOMARKERS FOR SCREENING OF PRE NEOPLASTIC LESIONS ASSOCIATED TO LUNG CANCER IN A RISK CHILEAN POPULATION | 2012 | JOURNAL OF THORACIC ONCOLOGY | ISI/UCH/VID | http://dx.doi.org/10.1097/JTO.0b013e318262df76 |
Contreras, A;Garcia, V;Salinas, F;Urzua, U;Ganga, MA;Martinez, C | Identification of genes related to nitrogen uptake in wine strains of Saccharomyces cerevisiae | 2012 | WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1007/s11274-011-0911-3 |
Castro, I;Aguilera, S;Brockhausen, I;Alliende, C;Quest, AFG;Molina, C;Urzua, U;Mandel, U;Bahamondes, V;Barrera, MJ;Sanchez, M;Gonzalez, S;Hermoso, M;Leyton, C;Gonzalez, MJ | Decreased salivary sulphotransferase activity correlated with inflammation and autoimmunity parameters in Sjogren’s syndrome patients | 2012 | RHEUMATOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1093/rheumatology/ker351 |
Barrera, MJ;Sanchez, M;Aguilera, S;Alliende, C;Bahamondes, V;Molina, C;Quest, AFG;Urzua, U;Castro, I;Gonzalez, S;Sung, HH;Albornoz, A;Hermoso, M;Leyton, C;Gonzalez, MJ | Aberrant localization of fusion receptors involved in regulated exocytosis in salivary glands of Sjogren’s syndrome patients is linked to ectopic mucin secretion | 2012 | JOURNAL OF AUTOIMMUNITY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jaut.2012.01.011 |
Sanchez, M;Aguilera, S;Barrera, MJ;Alliende, C;Bahamondes, V;Castro, I;Gonzalez, S;Molina, C;Leyton, C;Urzua, U;Sung, HH;Gonzalez, MJ | ALTERATIONS OF VAMP2 AND SINTAXIN-2 IN SALIVARY ACINAR CELLS MODIFY THE SECRETION PROCESS IN SJOGREN’S SYNDROME PATIENTS | 2012 | ANNALS OF THE RHEUMATIC DISEASES | ISI/UCH/VID | |
Urzua, U;Tapia, V;Geraldo, MP;Selman, A;Vega, M;Romero, C | Nerve Growth Factor Stimulates Cellular Proliferation of Human Epithelial Ovarian Cancer | 2012 | HORMONE AND METABOLIC RESEARCH | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1055/s-0032-1304617 |
Gonzalez, S ; Aguilera, S ; Urzua, U ; Quest, AFG ; Molina, C ; Alliende, C ; Hermoso, M ; Gonzalez, MJ | Mechanotransduction and epigenetic control in autoimmune diseases (vol 10, pg 175, 2011) | 2011 | AUTOIMMUNITY REVIEWS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.autrev.2011.03.002 |
Mattison, K ; Corneau, N ; Berg, I ; Bosch, A ; Duizer, E ; Gutierrez-Aguirre, I ; L’Homme, Y ; Lucero, Y ; Luo, ZY ; Martyres, A ; Myrmel, M ; O’Ryan, M ; Pagotto, F ; Sano, D ; Svraka, S ; Urzua, U ; Bidawid, S | Development and validation of a microarray for the confirmation and typing of norovirus RT-PCR products | 2011 | JOURNAL OF VIROLOGICAL METHODS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jviromet.2011.02.011 |
Gonzalez, S ; Aguilera, S ; Alliende, C ; Urzua, U ; Quest, AFG ; Herrera, L ; Molina, C ; Hermoso, M ; Ewert, P ; Brito, M ; Romo, R ; Leyton, C ; Perez, P ; Gonzalez, MJ | Alterations in Type I Hemidesmosome Components Suggestive of Epigenetic Control in the Salivary Glands of Patients With Sjogren’s Syndrome | 2011 | ARTHRITIS AND RHEUMATISM | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1002/art.30212 |
Bahamondes, V ; Albornoz, A ; Aguilera, S ; Alliende, C ; Molina, C ; Castro, I ; Urzua, U ; Quest, AFG ; Barrera, MJ ; Gonzalez, S ; Sanchez, M ; Hartel, S ; Hermoso, M ; Leyton, C ; Gonzalez, MJ | Changes in Rab3D Expression and Distribution in the Acini of Sjogren’s Syndrome Patients Are Associated With Loss of Cell Polarity and Secretory Dysfunction | 2011 | ARTHRITIS AND RHEUMATISM | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1002/art.30500 |
Gonzalez, S ; Aguilera, S ; Urzua, U ; Quest, AFG ; Molina, C ; Alliende, C ; Hermoso, M ; Gonzalez, MJ | Mechanotransduction and epigenetic control in autoimmune diseases | 2011 | AUTOIMMUNITY REVIEWS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.autrev.2010.09.022 |
Ewert, P ; Aguilera, S ; Alliende, C ; Kwon, YJ ; Albornoz, A ; Molina, C ; Urzua, U ; Quest, AFG ; Olea, N ; Perez, P ; Castro, I ; Barrera, MJ ; Romo, R ; Hermoso, M ; Leyton, C ; Gonzalez, MJ | Disruption of Tight Junction Structure in Salivary Glands From Sjogren’s Syndrome Patients Is Linked to Proinflammatory Cytokine Exposure | 2010 | ARTHRITIS AND RHEUMATISM | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1002/art.27362 |
Urzua, U ; Best, L ; Munroe, DJ | Microarray proteomic analysis discriminates tumorigenic mouse ovarian surface epithelial cells of divergent aggressive potential | 2010 | MOLECULAR BIOSYSTEMS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1039/c005220e |
Maldonado, V ; Espinosa, M ; Pruefer, F ; Patino, N ; Ceballos-Cancino, G ; Urzua, U ; Juretic, N ; Melendez-Zajgla, J | Gene Regulation by BCL3 in a Cervical Cancer Cell Line | 2010 | FOLIA BIOLOGICA | ISI;SCOPUS/UCH/VID | |
Urzua, U ; Owens, GA ; Zhang, GM ; Cherry, JM ; Sharp, JJ ; Munroe, DJ | Tumor and reproductive traits are linked by RNA metabolism genes in the mouse ovary: a transcriptome-phenotype association analysis | 2010 | BMC GENOMICS | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1186/1471-2164-11-S5-S1 |
Salinas, F ; Mandakovic, D ; Urzua, U ; Massera, A ; Miras, S ; Combina, M ; Ganga, MA ; Martinez, C | Genomic and phenotypic comparison between similar wine yeast strains of Saccharomyces cerevisiae from different geographic origins | 2010 | JOURNAL OF APPLIED MICROBIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1111/j.1365-2672.2010.04689.x |
Perez, P; Anaya, JM; Aguilera, S; Urzua, U; Munroe, D; Molina, C; Hermoso, MA; Cherry, JM; Alliende, C; Olea, N; Ruiz-Narvaez, E; Gonzalez, MJ | Gene expression and chromosomal location for susceptibility to Sjogren’s syndrome | 2009 | JOURNAL OF AUTOIMMUNITY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1016/j.jaut.2009.05.001 |
Juretic, N ; Urzua, U ; Munroe, DJ ; Jaimovich, E ; Riveros, N | Differential gene expression in skeletal muscle cells after membrane depolarization | 2007 | JOURNAL OF CELLULAR PHYSIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1002/jcp.20902 |
Urzua, U; Roby, KF; Gangi, LM; Cherry, JM; Powell, JI; Munroe, DJ | Transcriptomic analysis of an in vitro murine model of ovarian carcinoma: Functional similarity to the human disease and identification of prospective tumoral markers and targets | 2006 | JOURNAL OF CELLULAR PHYSIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1002/jcp.20522 |
Frankenberger C; Wu X; Harmon J; Church D; Gangi L.M; Munroe D.J; Urzua U. | WebaCGH: An interactive online tool for the analysis and display of array comparative genomic hybridisation data | 2006 | Applied Bioinformatics | SCOPUS/UCH/VID | http://dx.doi.org/10.2165/00822942-200605020-00009 |
Perez, P; Urzua, U; Munroe, D; Aguilera, S; Kwon, Y; Molina, C; Alliende, C; Leyton, C; Gonzalez, M | Transcriptional profile of the salivary gland epithelium in Sjogren’s syndrome patients | 2005 | ANNALS OF THE RHEUMATIC DISEASES | ISI/UCH/VID | |
Urzua, U; Frankenberger, C; Gangi, L; Mayer, S; Burkett, S; Munroe, DJ | Microarray comparative genomic hybridization profile of a murine model for epithelial ovarian cancer reveals genomic imbalances resembling human ovarian carcinomas | 2005 | TUMOR BIOLOGY | ISI;SCOPUS/UCH/VID | http://dx.doi.org/10.1159/000087378 |
Código proyecto | Título proyecto | Inicio | Fin | Investigador principal / Coinvestigadores | Institución / Unidad académica principal | Programa | Fuente |
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1130292 | Ovarian cancer initiation and spread in a syngeneic mouse model at estropausal state | 01-03-2013 | 01-03-2016 | U. Urzua / C. Romero; M. GONZÁLEZ | UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular | FONDECYT | Regular |
1120222 | Ski-containing transciptional co-repressor complexes on mitotic chromosomes repress the expression of selected target genes at early G1 | 01-03-2012 | 01-03-2015 | K. Marcelain / R. Armisen; U. Urzua | UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Genética Humana | FONDECYT | Regular |
1100477 | Biomarkers for identification Chilean infants at risk for respiratory suncytial virus (RSV) and rhinovirus (RV)- induced severe acute lower respiratory infection | 01-03-2010 | 01-03-2013 | C. Larrañaga / A. Gaggero; L. Tapia; M. Palomino; S. Ampuero; U. Urzua; V. Luchsinger | UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Virología | FONDECYT | Regular |
07CN13PBT-48 | Prevención y detección temprana de cáncer pulmonar con base en genómica e imageneología de punta | 01-12-2007 | 01-12-2010 | D. Gil / A. Quest; A. Undurraga; C. Del Castillo; M. Adonis; N. Juretic; U. Urzua; V. Martinez | UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular | INNOVA | Innova-interés público y precompetitivo |
I2 05/09-2 | Detección de alteraciones transcripcionales y genómicas en cáncer ovárico epitelial de diferentes estadios mediante tecnología de microarreglos de DNA | 01-07-2005 | 01-07-2007 | U. Urzua / C. Romero; M. GONZÁLEZ | UCH / Facultad de Medicina, Instituto de Ciencias Biomédicas, Programa de Biología Celular y Molecular | Fondo Central de Investigación | INICIACION |
Autor(es) | Título | Facultad | Año publicación | Profesor(es) guía | Comisión | Tema | Url | Fuente |
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Núñez Araos, Francisco Javier | Patrón de expresión de los genes eotaxina 2, Mip 1a, TLR-3, IRF-3 e IRF-7, en la co-infección por virus respiratorio sincicial y rhinovirus en células pulmonares NCI-H292 | Facultad de Medicina | 2016 | Ampuero Llanos, Sandra,;Urzúa Tobar, Ulises, | Infecciones por virus sincitial respiratorio;Genética;Infecciones por picornaviridae;Genética;Infecciones respiratorias;Genética;Coinfección células epiteliales;Virología;Quimiocina CCL24 | https://bibliotecadigital.uchile.cl/pri o-explore/fulldisplay?docid=uchile_alma 1120492520003936&context=L&vid= 6UDC_INST&search_scope=uchile_scope amp;tab=uchile_tab&lang=es_CL | B Digital | |
Núñez Araos, Francisco Javier | Patrón de expresión de los genes eotaxina 2, Mip 1a, TLR-3, IRF-3 e IRF-7, en la co-infección por virus respiratorio sincicial y rhinovirus en células pulmonares NCI-H292 / | Facultad de Medicina | 2016 | Ampuero Llanos, Sandra,;Urzúa Tobar, Ulises, | Infecciones por virus sincitial respiratorio;Genética.;INFECCIONES POR PICORNAVIRIDAE;Genética.;Infecciones respiratorias;Genética.;Coinfección células epiteliales;Virología;Quimiocina CCL24 | https://bibliotecadigital.uchile.cl/pri o-explore/fulldisplay?docid=uchile_alma 1120492520003936&context=L&vid= 6UDC_INST&search_scope=uchile_scope amp;tab=uchile_tab&lang=es_CL | B Digital |
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