PUBLICACIONES​ Del DOBC

Publicaciones

 -Año 2020-

  • Varela N., Lanas , Salazar L.A., Zambrano  T. (2020). The Current State of MicroRNAs as Restenosis Biomarkers. Front Genet 10: 1247. doi: 10.3389/fgene.2019.01247
  • Martínez M., Alveal E., Soto T., Ávila T., Flores I., Benavides C., Morales R., Bustamante E., Bangdiwala S., Varela N., Quiñones L.A. (2020). IL-6 -572C>G and CARD8 304T>A genetic polymorphisms are associated with the absolute neutrophil count in patients with hematological malignancies under chemotherapy: An application of Multilevel Model to a Pharmacogenetic preliminary study. Pharmacogenomics and Personalized Medicine 13: 337-343.
  • González-Martínez F, Sánchez-Rodas D., Varela N.M., Sandoval C., Quiñones L.A, Johnson-Restrepo B. (2020). As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking International Journal of Molecular Sciences Jul 8;21(14): E4832. doi: 10.3390/ijms21144832.
  • Castro-Santos P, Verdugo RA, Alonso-Arias R, Gutierrez MA, Quiñones LA, Suazo J, Aguillón JC, Olloquequi J, Pinochet C, Díaz-Peña R. Evidence of population-specific genetic profiles precluding generalization of SNP-wise associations with rheumatoid arthritis from Europeans and Asians to a Latin American admixed population. Sci Rep. (2020) 10:7879. https://doi.org/10.1038/s41598-020-64659-0
  • Escalante P., Barría T., Cancino M., Rahal M., Cerpa L., Sandoval C., Molina-Mellico L., Suárez M., Martínez M., Cáceres D., Quiñones L.A., Varela N. 2020. Genetic Polymorphisms as non-modifiable susceptibility factors to Laryngeal cancer. BioScience Reports 2020, 40, Apr 27. pii: BSR20191188, ISSN 0144-8463 IF 2018: 2,535. doi: 10.1042/BSR20191188.
  • Roco A., Nieto E, Suárez M., Rojo M., Bertoglia M.P., Verón G., Tamayo F., Arredondo A., Cruz D., Muñoz J., Bravo G., Salas P., Mejías F., Godoy G., Véliz P., Quiñones L. (2020). A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: A discovery cohort study. Frontiers in Pharmacology April 2020 | Volume 11 | Article 325, doi: 10.3389/fphar.2020.00325.
  • Rojo M., Roco A., Suarez M., Lavanderos M., Verón G., Bertoglia M.P., Arredondo A., Nieto E., Rubilar J.C., Tamayo F., Cruz D., Muñoz J., Bravo G., Salas P., Mejías F., Véliz P., Godoy G., Varela N., Llull G., Quiñones L. Functionally-significant coumarin-related variant alleles and time to therapeutic range in Chilean cardiovascular patients. Clin Appl Thr-Hemostasis 25: 1-7 (2020)
  • Urbina-Varela R., Soto-Espinoza M.I., Vargas R., Quiñones L.A.; del Campo A. (2020). Influence of BDNF genetic polymorphisms in the pathophysiology of aging-related diseases. Aging and Disease 11(6):1-14.
  • D’Afonseca V., Arencibia AD., Echeverría-Vega A., Cerpa L., Cayún JP., Varela N., Salazar M., Quiñones L.A. Identification of altered genes in gallbladder cancer as potential driver mutations for diagnostic and prognostic purposes: a computational approach. Cancer Informatics 2020. 19: 1-4. https://doi.org/10.1177/11769351209221.
  • Canesin G, Maggio V, Palominos M, Stiehm A, Contreras HR, Castellón EA, Morote J, Paciucci R, Maitland NJ, Bjartell A, Hellsten R. STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population Sci Rep. (2020) Aug 18;10(1):13958. doi: 10.1038/s41598 -020-70948-5. IF: 4,122
  • Figueroa D, Signore A, Araneda O, Contreras HR, Concha M, García C. Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. J Toxicol Environ Health A. (2020) Aug 17;83(15-16):573-588. doi: 10.1080/15287394. (2020).1793046. Epub (2020) Jul 19. IF: 2,88
  • Rivas J, Díaz N, Silva I, Morales D, Lavanderos B, Álvarez A, Saldías MP, Pulgar E, Cruz P, Maureira D, Flores G, Colombo A, Blanco C, Contreras HR, Jaña F, Gallegos I, Concha ML, Vergara-Jaque A, Poblete H, González W, Varela D, Trimmer JS, Cáceres M, Cerda O. KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis. FASEB J. (2020) Apr 17. doi: 10.1096/fj.(2019)01195RRR. Online ahead of print. IF: 5,391
  • Jimenez-Cárcamo D, García C, Contreras HR. Toxins of Okadaic Acid OA-Group Increase Malignant Properties in Cells of Colon Cancer. Toxins (Basel). (2020) Mar 13;12(3):179. doi: 10.3390/toxins1203017. IF: 3,897
  • Contreras HR, López-Moncada F, Castellón, EA. Cancer stem cells and mesenchymal cells cooperative action in metastasis progression and hormone resistance in prostate cancer: Potential role of stemness genes, androgen and GnRH receptors. (2020) International Journal of Oncology May;56(5):1075-1082. doi: 10.3892/ijo.(2020).5008. Epub (2020) Mar 5.Int J Oncol. (2020.PMID: 32319606 IF: 3.45
  • Farfán N, Orellana-Serradell O, Herrera D, Chrzanowsky D, Cubillos P, Marín G, Antonio García De Herreros A, Castellón EA, Contreras HR. SNAIL expression correlates with the translocation of Syndecan 1 intracellular domain into the nucleus in prostate cancer cell lines. International Journal Molecular Medicine (2020) Apr;45(4):1073-1080. doi: 10.3892/ijmm.(2020).4488. Epub (2020) Feb 5. IF: 2.996
  • Campolina-Silva GH, Werneck-Gomes H, Maria BT, Barata MC, Torres MJ, Contreras HR, Mahecha GAB, Oliveira CA. Targeting Wistar rat as a model for studying benign, premalignant and malignant lesions of the prostate. Life Sci. (2020) Feb 1;242:117149. doi: 10.1016/j.lfs.2019.117149. Epub 2019 Dec 9. PubMed PMID: 31830481.
  • Urzúa U, Chacón C, Norambuena M, Lizama L, Sarmiento S, Asaki E, Powell JI, Ampuero S. The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection. Biomolecules. (2020) Jan 9;10(1). pii: E113. doi: 10.3390/biom10010113. PubMed PMID: 31936467.

 

 -Año 2019-

  • López-Moncada F, Torres MJ, Castellón EA, Contreras HR. Secreted protein acidic and rich in cysteine (SPARC) induces epithelial-mesenchymal transition, enhancing migration and invasion, and is associated with high Gleason score in prostate cancer. Asian J Androl. 2019 Nov-Dec;21(6):557-564. doi: 10.4103/aja.aja_23_19. PubMed PMID: 31031331; PubMed Central PMCID: PMC6859668.
  • Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F. Curcumin decreases epithelial‑mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Nov;42(5):2139-2148. doi: 10.3892/or.2019.7288. Epub 2019 Aug 21. PubMed PMID: 31436299.
  • López-Cortés A, Paz-Y-Miño C, Guerrero S, Jaramillo-Koupermann G, León Cáceres Á, Intriago-Baldeón DP, García-Cárdenas JM, Guevara-Ramírez P, Armendáriz-Castillo I, Leone PE, Quiñones LA, Cayún JP, Soria NW. Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. Pharmacogenomics J. 2019 Oct 15. doi: 10.1038/s41397-019-0102-4. [Epub ahead of print] Review. PubMed PMID: 31616044.
  • Landskron G, De la Fuente López M, Dubois-Camacho K, Díaz-Jiménez D, Orellana-Serradell O, Romero D, Sepúlveda SA, Salazar C, Parada-Venegas D, Quera R, Simian D, González MJ, López-Köstner F, Kronberg U, Abedrapo M, Gallegos I, Contreras HR, Peña C, Díaz-Araya G, Roa JC, Hermoso MA. Corrigendum: Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer. Front Immunol. 2019 Sep 24;10:2149. doi: 10.3389/fimmu.2019.02149. eCollection 2019. PubMed PMID: 31595174; PubMed Central PMCID: PMC6769820.
  • Grijalva-Avila J, Villanueva-Fierro I, Lares-Asseff I, Chairez-Hernández I, Rivera-Sanchez G, Martínez-Estrada S, Martínez-Rivera I, Quiñones LA, Loera-Castañeda V. Milk intake and IGF-1 rs6214 polymorphism as protective factors to obesity. Int J Food Sci Nutr. 2019 Sep 18:1-6. doi:10.1080/09637486.2019.1666805. [Epub ahead of print] PubMed PMID: 31530040.
  • Orellana-Serradell O, Herrera D, Castellón EA, Contreras HR. The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines. Asian J Androl. 2019 Sep-Oct;21(5):460-467. doi: 10.4103/aja.aja_1_19. PubMed PMID:30880686; PubMed Central PMCID: PMC6732893.
  • Alvarado ÁT, Muñoz AM, Loja B, Miyasato JM, García JA, Cerro RA, Quiñones LA, Varela N. Study of the allelic variants CYP2C9*2 and CYP2C9*3 in samples of the Peruvian mestizo population. Biomedica. 2019 Sep 1;39(3):601-610. doi:10.7705/biomedica.4636. English, Spanish. PubMed PMID: 31584773.
  • Roco A, Lavanderos A, Cayún JP, Acevedo C, Celedón C, Rubilar JC, Sandoval C, Cerpa L, García-Martín E, Agúndez JA, Esguevillas G, Amo G, Canepa A, Cerda B, Peña K, Cáceres DD, Varela N, Quiñones LA. The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer. Pharmacogenet Genomics. 2019 Sep;29(7):159-166. doi: 10.1097/FPC.0000000000000379. PubMed PMID: 31107374.
  • Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro. Rheumatology (Oxford). 2019 Aug 3. pii: kez316. doi:10.1093/rheumatology/kez316. [Epub ahead of print] PubMed PMID: 31377809.
  • Landskron G, De la Fuente López M, Dubois-Camacho K, Díaz-Jiménez D, Orellana-Serradell O, Romero D, Sepúlveda SA, Salazar C, Parada-Venegas D, Quera R, Simian D, González MJ, López-Köstner F, Kronberg U, Abedrapo M, Gallegos I, Contreras HR, Peña C, Díaz-Araya G, Roa JC, Hermoso MA. Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer. Front Immunol. 2019 Jun 21;10:1394. doi:10.3389/fimmu.2019.01394. eCollection 2019. Erratum in: Front Immunol. 2019 Sep 24;10:2149. PubMed PMID: 31281317; PubMed Central PMCID: PMC6598075.
  • Castellón EA. Patient-derived organoids: New co-clinical model to predict treatment response in cancer? Oral Dis. 2019 May;25(4):928-930. doi:10.1111/odi.12988. Epub 2018 Oct 30. PubMed PMID: 30281877.
  • Lavanderos MA, Cayún JP, Roco Á, Sandoval C, Cerpa L, Rubilar JC, Cerro R, Molina-Mellico S, Celedón C, Cerda B, García-Martín E, Agúndez JAG, Acevedo C, Peña K, Cáceres DD, Varela N, Quiñones LA. Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients. Front Pharmacol. 2019 Mar 8;10:206. doi:10.3389/fphar.2019.00206. eCollection 2019. PubMed PMID: 30914949; PubMed Central PMCID: PMC6421934.
  • Sagredo AI, Sagredo EA, Pola V, Echeverría C, Andaur R, Michea L, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines. J Cell Physiol. 2019 Mar;234(3):2037-2050. doi: 10.1002/jcp.27371. Epub 2018 Oct 21. PubMed PMID: 30343491.
  • Cortés J, Hidalgo J, Aguilera S, Castro I, Brito M, Urra H, Pérez P, Barrera MJ, Carvajal P, Urzúa U, González S, Molina C, Bahamondes V, Hermoso M, González MJ. Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients. J Autoimmun. 2019 Feb;97:88-99. doi: 10.1016/j.jaut.2018.10.019. Epub 2018 Oct 31. PubMed PMID:30391023.
  • Herrera D, Orellana-Serradell O, Villar P, Torres MJ, Paciucci R, Castellón EA, Contreras HR. Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells. Oncol Rep. 2019 Feb;41(2):1275-1283. doi: 10.3892/or.2018.6885. Epub 2018 Nov 26. PubMed PMID: 30483800.
  • Nieto E, Suarez M, Roco Á, Rubilar JC, Tamayo F, Rojo M, Verón G, Sepúlveda J, Mejías F, Salas P, Góngora M, Andrade P, Canales A, Carabantes J, Cruz D, Contreras E, Pavez D, Charo P, Bravo G, Calderón J, Gallardo C, Vega P, Quiñones LA. Anticoagulation Management With Coumarinic Drugs in Chilean Patients. Clin Appl Thromb Hemost. 2019 Jan-Dec;25:1076029619834342. doi:10.1177/1076029619834342. PubMed PMID: 30880431; PubMed Central PMCID: PMC6714932.

 -Año 2018-

  • González-Martínez F, Sánchez-Rodas D, Cáceres DD, Martínez MF, Quiñones LA, Johnson-Restrepo B. Arsenic exposure, profiles of urinary arsenic species, and polymorphism effects of glutathione-s-transferase and metallothioneins. Chemosphere. 2018 Dec;212:927-936. doi:10.1016/j.chemosphere.2018.08.139. Epub 2018 Aug 28. PubMed PMID: 30286549.
  • Lagos C, Carvajal P, Castro I, Jara D, González S, Aguilera S, Barrera MJ, Quest AFG, Bahamondes V, Molina C, Urzúa U, Hermoso MA, Leyton C, González MJ. Association of high 5-hydroxymethyl cytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients. Clin Immunol. 2018 Nov;196:85-96. doi: 10.1016/j.clim.2018.06.002. Epub 2018 Jun 9. PubMed PMID: 29894742.
  • Sagredo EA, Blanco A, Sagredo AI, Pérez P, Sepúlveda-Hermosilla G, Morales F, Müller B, Verdugo R, Marcelain K, Harismendy O, Armisén R. ADAR1-mediated RNA-editing of 3'UTRs in breast cancer. Biol Res. 2018 Oct 5;51(1):36. doi:10.1186/s40659-018-0185-4. PubMed PMID: 30290838; PubMed Central PMCID: PMC6172785.
  • Roco Á, Cerda B, Cayún JP, Lavanderos A, Rubilar JC, Cerro R, Acevedo C, Cáceres D, Varela N, Quiñones LA. [Pharmacogenetics, tobacco, alcohol and its effect on the risk development cancer]. Rev Chil Pediatr. 2018 Aug;89(4):432-440. doi: 10.4067/S0370-41062018005000709. Review. Spanish. PubMed PMID: 30571815.
  • Farfán N, Ocarez N, Castellón EA, Mejía N, de Herreros AG, Contreras HR. The transcriptional factor ZEB1 represses Syndecan 1 expression in prostate cancer. Sci Rep. 2018 Jul 31;8(1):11467. doi: 10.1038/s41598-018-29829-1. PubMed PMID: 30065348; PubMed Central PMCID: PMC6068163.
  • Sepúlveda D, Barrera MJ, Castro I, Aguilera S, Carvajal P, Lagos C, González S, Albornoz N, Bahamondes V, Quest AFG, Urzúa U, Molina C, Leyton C, Hermoso MA, González MJ. Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren's syndrome patients. Rheumatology (Oxford). 2018 Jun 1;57(6):1021-1032. doi: 10.1093/rheumatology/key021. PubMed PMID: 29534223.
  • Andaur R, Tapia JC, Moreno J, Soto L, Armisen R, Marcelain K. Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells. Oncotarget. 2018 May 29;9(41):26387-26405. doi: 10.18632/oncotarget.25405. eCollection 2018 May 29. PubMed PMID: 29899866; PubMed Central PMCID: PMC5995186.
  • Calaf GM, Urzua U, Termini L, Aguayo F. Oxidative stress in female cancers. Oncotarget. 2018 May 4;9(34):23824-23842. doi: 10.18632/oncotarget.25323. eCollection 2018 May 4. Review. PubMed PMID: 29805775; PubMed Central PMCID: PMC5955122.
  • Orellana-Serradell O, Herrera D, Castellón EA, Contreras HR. The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines. Asian J Androl. 2018 May-Jun;20(3):294-299. doi: 10.4103/aja.aja_61_17. PubMed PMID: 29271397; PubMed Central PMCID: PMC5952486.
  • Urzúa U, Chacon C, Espinoza R, Martínez S, Hernandez N. Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary. Anal Cell Pathol (Amst). 2018 Mar 15;2018:1289103. doi: 10.1155/2018/1289103. eCollection 2018. PubMed PMID: 29736365; PubMed Central PMCID: PMC5874974.
  • Sagredo AI, Sagredo EA, Cappelli C, Báez P, Andaur RE, Blanco C, Tapia JC, Echeverría C, Cerda O, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells. Mol Oncol. 2018 Feb;12(2):151-165. doi: 10.1002/1878-0261.12100. Epub 2017 Dec 30. PubMed PMID: 28614631; PubMed Central PMCID: PMC5792731.
  • Ampuero S, Andaur R, Milano M, Moreno M, Lizama L, Larrañaga C, Urzúa U. Time-course of transcriptome response to respiratory syncytial virus infection in lung epithelium cells. Acta Virol. 2018;62(3):310-325. doi: 10.4149/av_2018_225. PubMed PMID: 30160147.

 -Año 2017-

  • Carrillo D, Muñoz JP, Huerta H, Leal G, Corvalán A, León O, Calaf GM, Urzúa U, Boccardo E, Tapia JC, Aguayo F. Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells. Open Biol. 2017 Nov;7(11). pii: 170111. doi: 10.1098/rsob.170111. PubMed PMID: 29118270; PubMed Central PMCID: PMC5717337.
  • Urzua U, Chacon C, Lizama L, Sarmiento S, Villalobos P, Kroxato B, Marcelain K, Gonzalez MJ. Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice. Aging Dis. 2017 Oct 1;8(5):546-557. doi: 10.14336/AD.2017.0110. eCollection 2017 Oct. PubMed PMID: 28966800; PubMed Central PMCID: PMC5614320.
  • Lorenzo Bermejo J, Boekstegers F, González Silos R, Marcelain K, Baez Benavides P, Barahona Ponce C, Müller B, Ferreccio C, Koshiol J, Fischer C, Peil B, Sinsheimer J, Fuentes Guajardo M, Barajas O, Gonzalez-Jose R, Bedoya G, Cátira Bortolini M, Canizales-Quinteros S, Gallo C, Ruiz Linares A, Rothhammer F. Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. PLoS Genet. 2017 May 25;13(5):e1006756. doi: 10.1371/journal.pgen.1006756. eCollection 2017 May. PubMed PMID: 28542165; PubMed Central PMCID: PMC5444600.
  • López-Cortés A, Guerrero S, Redal MA, Alvarado AT, Quiñones LA. State of Art of Cancer Pharmacogenomics in Latin American Populations. Int J Mol Sci. 2017 May 23;18(6). pii: E639. doi: 10.3390/ijms18060639. Review. PubMed PMID: 28545225; PubMed Central PMCID: PMC5485925.