PUBLICACIONES​ Del DOBC

Publicaciones

-Año 2021-

  1. Salas-Hernández A, Ruz-Cortés F, Bruggendieck F, Espinoza-Perez C, Espitia-Corredor J, Varela NM, Quiñones LA, Sánchez-Ferrer C, Peiró C, Díaz-Araya G. Resolvin D1 reduces expression and secretion of cytokines and monocyte adhesion triggered by Angiotensin II, in rat cardiac fibroblasts. Biomed Pharmacother. 2021 Jul 18;141:111947. doi: 10.1016/j.biopha.2021.111947. Epub ahead of print. PMID: 34328122. IF: 6.529.
  2. Hanker AB, Brown BP, Meiler J, Marín A, Jayanthan HS, Ye D, Lin CC, Akamatsu H, Lee KM, Chatterjee S, Sudhan DR, Servetto A, Brewer MR, Koch JP, Sheehan JH, He J, Lalani AS, Arteaga CL. Co-occurring gain-of-function mutations in HER2 and HER3 modulate HER2/HER3 activation, oncogenesis, and HER2 inhibitor sensitivity. Cancer Cell. 2021 Jun 22:S1535-6108(21)00284-1. doi: 10.1016/j.ccell.2021.06.001. IF: 31,743.
  3. Young RM, Solis-Cascante CJ, Barriga-Fehrman A, Abogabir C, Thadani AR, Labarca M, Bustamante E, Tapia CV, Sarda AG, Sepulveda F, Pozas N, Cerpa LC, Lavanderos MA, Varela NM, Santibañez A, Sandino AM, Reyes-Lopez F, Dixon G, Quiñones LA. Smartphone Screen Testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals. Elife. 2021 Jun 22;10:e70333. doi: 10.7554/eLife.70333. IF: 8,140.
  4. Torres MJ, López-Moncada F, Herrera D, Indo S, Lefian A, Llanos P, Tapia J, Castellón EA, Contreras HR. Endothelin-1 induces changes in the expression of steroidogenic enzymes and increases androgen receptor and testosterone production in prostate cancer cells. Oncology Reports. 2021; 46: 171-182. doi: 10.3892/or.2021.8122. IF: 3,906.
  5. Carriere P, Calvo N, Novoa Díaz MB, Lopez-Moncada F, Herrera A, Torres MJ, Alonso E, Gandini NA, Gigola G, Contreras HR, Gentili C. Role of SPARC in the epithelial-mesenchymal transition induced by PTHrP in human colon cancer cells. Mol Cell Endocrinol. 2021 Jun 15;530:111253. doi: 10.1016/j.mce.2021.111253. IF: 3,760.
  6. Pérez G, López-Moncada F, Torres MJ, Castellón EA, Contreras HR. Knockdown of ZEB1 reverse cancer stem cell properties in prostate cancer cells. Oncology Reports. 2021 May;45(5):58. doi: 10.3892/or.2021.8009. IF: 3,906.
  7. Perez-Dominguez F, Carrillo-Beltrán D, Blanco R, Muñoz JP, León-Cruz G, Corvalan AH, Urzúa U, Calaf GM, Aguayo F. Role of Pirin, an Oxidative Stress Sensor Protein, in Epithelial Carcinogenesis. Biology (Basel). 2021 Feb 4;10(2):116. IF: 5,010.
  8. Leal B., Torres H., Roco A., Román R., Rojo M, Nieto E., Quiñones L.A. Impacto de la atención farmacéutica en la calidad del tratamiento con acenocumarol en pacientes con fibrilación auricular del Hospital San Luis de Buin. Revista Médica de Chile. 2021 (accepted). IF: 0,533.
  9. Quiñones L.A., Salas-Hernández A. Análisis y consideraciones técnicas acerca de dispositivos intrauterinos de Levonorgestrel para la evaluación de productos similares y genéricos. Revista Médica Clínica las Condes. 202132(4): 502-510. https://doi.org/10.1016/j.rmclc.2021.04.005. IF: 0,000.
  10. Cavieres M, Suárez M, Verón G, Quiñones LA, Varela NM. Análisis farmacogenético retrospectivo de paciente pediátrica en tratamiento anticoagulante: caso clínico. Biomédica. 2021;41 (4). IF: 0,935.
  11. Poblete D., Bernal F., Llull G., Archiles S., Vasquez P., Chanqueo L., Soto N., Lavanderos M.A., Quiñones L.A., Varela N.M. Pharmacogenetic associations between Atazanavir/UGT1A1*28 and Efavirenz/rs3745274 (CYP2B6) account for specific adverse reactions in Chilean patients undergoing antiretroviral treatment. Frontiers in Pharmacology May 2021; Volume 12: Article 660965. IF: 5,810.
  12. Gonzalez-Hormazabal P, Pelaez D, Musleh M, Bustamante M, Stambuk J, Pisano R, Valladares H, Lanzarini E, Chiong H, Suazo J, Quiñones LA, Varela NM, Castro VG, Jara L, Berger Z. NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori. Biol Res. 2021 Apr 20;54(1):13. doi: 10.1186/s40659-021-00336-4. IF: 5,612.
  13. Varela N.M., Guevara-Ramírez P., Acevedo C., Zambrano T, Armendáriz-Castillo I., Guerrero S., Quiñones L.A, López-Cortés A. A New Insight for the Identification of Oncogenic Variants in Breast and Prostate Cancers in Diverse Human Populations, With a Focus on Latinos. Frontiers in Pharmacology, April 2021; Volume 12: Article 630658. doi: 10.3389/fphar.2021.630658. IF: 5,810.
  14. Martínez M.F. Alveal E., Soto T., Bustamante E., Ávila F., Bangdiwala S., Flores I., Benavides C., Morales R., Varela N.M., QuiñonesA. Pharmacogenetics – based preliminary algorithm to predict the incidence of infection in patients receiving cytotoxic chemotherapy for hematological malignancies: a discovery cohort. Frontiers in Pharmacology March 2021; Volume 12: Article 602676. doi: 10.3389/fphar.2021. 602676. IF: 5,810.
  15. López-Cortés A, Guevara-Ramírez P, Kyriakidis NC, Barba-Ostria C, León Cáceres Á, Guerrero S, Ortiz-Prado E, Munteanu CR, Tejera E, Cevallos-Robalino D, Gómez-Jaramillo AM, Simbaña-Rivera K, Granizo-Martínez A, Pérez-M G, Moreno S, García-Cárdenas JM, Zambrano AK, Pérez-Castillo Y, Cabrera-Andrade A, Puig San Andrés L, Proaño-Castro C, Bautista J, Quevedo A, Varela N, Quiñones LA, Paz-Y-Miño C. In silico Analyses of Immune System Protein Interactome Network, Single-Cell RNA Sequencing of Human Tissues, and Artificial Neural Networks Reveal Potential Therapeutic Targets for Drug Repurposing Against COVID-19. Front Pharmacol. 2021 Feb 26;12:598925. doi: 10.3389/fphar.2021.598925. IF: 5,810.
  16. Castillo AF, Orlando UD, Maloberti PM, Prada JG, Dattilo MA, Solano AR, Bigi MM, Ríos Medrano MA, Torres MT, Indo S, Caroca G, Contreras HR, Marelli BE, Salinas FJ, Salvetti NR, Ortega HH, Lorenzano Menna P, Szajnman S, Gomez DE, Rodríguez JB, Podesta EJ. New inhibitor targeting Acyl-CoA synthetase 4 reduces breast and prostate tumor growth, therapeutic resistance and steroidogenesis. Cell Mol Life Sci. 2021 Mar;78(6):2893-2910. doi: 10.1007/s00018-020-03679-5. IF: 9,261.
  17. Escalante PI, Quiñones LA, Contreras HR. Epithelial-Mesenchymal Transition and MicroRNAs in Colorectal Cancer Chemoresistance to FOLFOX. 2021; 13(1):75. https://doi.org/10.3390/pharmaceutics13010075. IF: 6,321.
  18. de Santiago PR, Blanco A, Morales F, Marcelain K, Harismendy O, Sjöberg Herrera M, Armisén R. Immune-related IncRNA LINC00944 responds to variations in ADAR1 levels and it is associated with breast cancer prognosis. Life Sci. 2021 Mar 1;268:118956. doi: 10.1016/j.lfs.2020.118956. IF: 5,037.
  19. Barahona Ponce C, Scherer D, Brinster R, Boekstegers F, Marcelain K, Gárate-Calderón V, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, Fischer C, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Bonet C, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales-Quinteros S, Gallo C, Ruiz-Linares A, Rothhammer F, Lorenzo Bermejo J. Gallstones, Body Mass Index, C-Reactive Protein, and Gallbladder Cancer: Mendelian Randomization Analysis of Chilean and European Genotype Data. 2021; 73(5):1783-1796. doi: 10.1002/hep.31537. IF: 17,425.
  20. San Martin E, Carvajal F, Cifuentes A, et al. Overall Survival in Patients With Resected Glioblastoma Treated With Adjuvant Therapy: A Retrospective Study in a Public Hospital in Chile. Cureus 2021 (may 18). 13(5): e15105. doi. 10.7759/cureus.15105. IF: 0,270.
  21. Carvajal F, Carvajal C, Merino T, López V, Retamales J, San Martín E, Alarcón F, Cuevas M, Barahona F, Véliz I, Ríos JA, Becerra S. Radiotherapy for cervical cancer: Chilean consensus of the Society of Radiation Oncology. Rep Pract Oncol Radiother 2021;26(2):291–302. doi: 10.5603/RPOR.a2021.0025. IF: 1,700.
  22. Brägelmann J, Barahona Ponce C, Marcelain K, Roessler S, Goeppert B, Gallegos I, Colombo A, Sanhueza V, Morales E, Rivera MT, de Toro G, Ortega A, Müller B, Gabler F, Scherer D, Waldenberger M, Reischl E, Boekstegers F, Garate-Calderon V, Umu SU, Rounge TB, Popanda O, Lorenzo Bermejo J. Epigenome-Wide Analysis of Methylation Changes in the Sequence of Gallstone Disease, Dysplasia, and Gallbladder Cancer. Hepatology. 2021 Jun;73(6):2293-2310. doi: 10.1002/hep.31585. IF: 17,425.
  23. Castro SM., Segui GV., Contreras JMR., Cardemil FM. Actualización en carcinoma escamoso orofaríngeo. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2021; 81: 291-305. IF: 0,000.
  24. Castro SM., Cardemil FM. Criterios de calidad en el manejo de pacientes con cáncer de cabeza y cuello. Rev. Cir. 2021;73(2):227-228. IF: 0,000.
  25. Castro SM., Bugueño MV., Contreras JMR., Cardemil FM. Colgajo en isla submental: Experiencia de 2 casos en reconstrucción de base de cráneo lateral. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2021; 81: 72-77. IF: 0,000.

-Año 2020-

  1. Varela N., Lanas, Salazar L.A., Zambrano (2020). The Current State of MicroRNAs as Restenosis Biomarkers. Front Genet 10: 1247. doi: 10.3389/fgene.2019.01247. IF: 4,599.
  2. Martínez M., Alveal E., Soto T., Ávila T., Flores I., Benavides C., Morales R., Bustamante E., Bangdiwala S., Varela N., Quiñones L.A. IL-6 -572C>G and CARD8 304T>A genetic polymorphisms are associated with the absolute neutrophil count in patients with hematological malignancies under chemotherapy: An application of Multilevel Model to a Pharmacogenetic preliminary study. Pharmacogenomics and Personalized Medicine, 2020; 13: 337-343. IF: 3,912.
  3. González-Martínez F, Sánchez-Rodas D., Varela N.M., Sandoval C., Quiñones L.A, Johnson-Restrepo B. As3MT and GST Polymorphisms Influencing Arsenic Metabolism in Human Exposure to Drinking. International Journal of Molecular Sciences, 2020; Jul 8;21(14): E4832. doi: 10.3390/ijms21144832. IF: 5,923.
  4. Castro-Santos P, Verdugo RA, Alonso-Arias R, Gutierrez MA, Quiñones LA, Suazo J, Aguillón JC, Olloquequi J, Pinochet C, Díaz-Peña R. Evidence of population-specific genetic profiles precluding generalization of SNP-wise associations with rheumatoid arthritis from Europeans and Asians to a Latin American admixed population. Sci Rep. 2020; 10:7879. https://doi.org/10.1038/s41598-020-64659-0. IF: 4,379.
  5. Escalante P., Barría T., Cancino M., Rahal M., Cerpa L., Sandoval C., Molina-Mellico L., Suárez M., Martínez M., Cáceres D., Quiñones L.A., Varela N. Genetic Polymorphisms as non-modifiable susceptibility factors to Laryngeal cancer. BioScience Reports, 2020; 40, Apr 27. pii: BSR20191188, ISSN 0144-8463 IF 2018: 2,535. doi: 10.1042/BSR20191188. IF: 3,840.
  6. Roco A., Nieto E, Suárez M., Rojo M., Bertoglia M.P., Verón G., Tamayo F., Arredondo A., Cruz D., Muñoz J., Bravo G., Salas P., Mejías F., Godoy G., Véliz P., Quiñones L. (2020). A pharmacogenetically-guided acenocoumarol dosing algorithm for Chilean patients: A discovery cohort study. Frontiers in Pharmacology, April 2020;| Volume 11: Article 325, doi: 10.3389/fphar.2020.00325. IF: 5,810.
  7. Rojo M., Roco A., Suarez M., Lavanderos M., Verón G., Bertoglia M.P., Arredondo A., Nieto E., Rubilar J.C., Tamayo F., Cruz D., Muñoz J., Bravo G., Salas P., Mejías F., Véliz P., Godoy G., Varela N., Llull G., Quiñones L. Functionally-significant coumarin-related variant alleles and time to therapeutic range in Chilean cardiovascular patients. Clin Appl Thr-Hemostasis, 2020; 25: 1-7. IF: 2,389.
  8. Urbina-Varela R., Soto-Espinoza M.I., Vargas R., Quiñones L.A.; del Campo A. Influence of BDNF genetic polymorphisms in the pathophysiology of aging-related diseases. Aging and Disease, 2020; 11(6):1-14. IF: 6,745.
  9. D’Afonseca V., Arencibia AD., Echeverría-Vega A., Cerpa L., Cayún JP., Varela N., Salazar M., Quiñones L.A. Identification of altered genes in gallbladder cancer as potential driver mutations for diagnostic and prognostic purposes: a computational approach. Cancer Informatics, 2020. 19: 1-4. https://doi.org/10.1177/11769351209221. IF: 0,555.
  10. Roco A., Nieto E., Quintana M., Muñoz J., Ortíz V., Moreno M., Mejías F., Godoy G., Zambrano J., Bruna S., Bravo G., Cabrera C., Salas P., Moena V., Leal V., Suárez M., Quiñones L.A. Comparison of point of care capillary international normalized ratio (INR) with INR measured in venous samples. Rev Med Chile, 2020; 147: 1109-1117.IF: 0,553.
  11. López-Cortés A, Paz-Y-Miño C, Guerrero S, Jaramillo-Koupermann G, León Cáceres Á, Intriago-Baldeón DP, García-Cárdenas JM, Guevara-Ramírez P, Armendáriz-Castillo I, Leone PE, Quiñones LA, Cayún JP, Soria NW. Pharmacogenomics, biomarker network, and allele frequencies in colorectal cancer. Pharmacogenomics J. 2020;20(1):136-158. doi: 10.1038/s41397-019-0102-4. IF: 3,550.
  12. Canesin G, Maggio V, Palominos M, Stiehm A, Contreras HR, Castellón EA, Morote J, Paciucci R, Maitland NJ, Bjartell A, Hellsten R. STAT3 inhibition with galiellalactone effectively targets the prostate cancer stem-like cell population. Sci Rep. 2020; Aug 18;10(1):13958. doi: 10.1038/s41598 -020-70948-5. IF: 4,379.
  13. Figueroa D, Signore A, Araneda O, Contreras HR, Concha M, García C. Toxicity and differential oxidative stress effects on zebrafish larvae following exposure to toxins from the okadaic acid group. J Toxicol Environ Health A. 2020; Aug 17;83(15-16):573-588. doi: 10.1080/15287394. IF: 2,772.
  14. Rivas J, Díaz N, Silva I, Morales D, Lavanderos B, Álvarez A, Saldías MP, Pulgar E, Cruz P, Maureira D, Flores G, Colombo A, Blanco C, Contreras HR, Jaña F, Gallegos I, Concha ML, Vergara-Jaque A, Poblete H, González W, Varela D, Trimmer JS, Cáceres M, Cerda O. KCTD5, a novel TRPM4-regulatory protein required for cell migration as a new predictor for breast cancer prognosis. FASEB J. 2020; Jun;34(6):7847-7865. doi: 10.1096/fj.201901195RRR. IF: 5,191.
  15. Jimenez-Cárcamo D, García C, Contreras HR. Toxins of Okadaic Acid OA-Group Increase Malignant Properties in Cells of Colon Cancer. Toxins (Basel). (2020) Mar 13;12(3):179. doi: 10.3390/toxins1203017. IF: 4,546.
  16. Contreras HR, López-Moncada F, Castellón, EA. Cancer stem cells and mesenchymal cells cooperative action in metastasis progression and hormone resistance in prostate cancer: Potential role of stemness genes, androgen and GnRH receptors. International Journal of Oncology, 2020; 56(5):1075-1082. doi: 10.3892/ijo.2020.5008. IF: 5,650.
  17. Farfán N, Orellana-Serradell O, Herrera D, Chrzanowsky D, Cubillos P, Marín G, Antonio García De Herreros A, Castellón EA, Contreras HR. SNAIL expression correlates with the translocation of Syndecan 1 intracellular domain into the nucleus in prostate cancer cell lines. International Journal Molecular Medicine, 2020; Apr;45(4):1073-1080. doi: 10.3892/ijmm.2020.4488. IF: 4,101.
  18. Campolina-Silva GH, Werneck-Gomes H, Maria BT, Barata MC, Torres MJ, Contreras HR, Mahecha GAB, Oliveira CA. Targeting Wistar rat as a model for studying benign, premalignant and malignant lesions of the prostate. Life Sci. 2020; 242:117149. doi: 10.1016/j.lfs.2019.117149. IF: 5,037.
  19. Urzúa U, Chacón C, Norambuena M, Lizama L, Sarmiento S, Asaki E, Powell JI, Ampuero S. The Ovarian Transcriptome of Reproductively Aged Multiparous Mice: Candidate Genes for Ovarian Cancer Protection. Biomolecules. 2020; Jan 9;10(1). pii: E113. doi: 10.3390/biom10010113. IF: 4,879.
  20. Sapoznik E, Chang BJ, Huh J, Ju RJ, Azarova EV, Pohlkamp T, Welf ES, Broadbent D, Carisey AF, Stehbens SJ, Lee KM, Marín A, Hanker AB, Schmidt JC, Arteaga CL, Yang B, Kobayashi Y, Tata PR, Kruithoff R, Doubrovinski K, Shepherd DP, Millett-Sikking A, York AG, Dean KM, Fiolka RP. A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. 2020 Nov 12;9:e57681. doi: 10.7554/eLife.57681. IF: 8,140.
  21. González-Montero J, Del Valle-Batalla L, Castillo-Astorga R, Marín Valdés A, Conte Lanza G. JAK2V617F mutation prevalence on Chilean adults suffering from primary mesenteric and portal venous thromboses. Int J Lab Hematol. 2020 Jun;42(3):331-334. doi: 10.1111/ijlh.13184. IF: 2,877.
  22. Cappelli C, Sepulveda H, Rivas S, Pola V, Urzúa U, Donoso G, Sagredo E, Carrero D, Casanova-Ortiz E, Sagredo A, González M, Manterola M, Nardocci G, Armisén R, Montecino M, Marcelain K. Ski Is Required for Tri-Methylation of H3K9 in Major Satellite and for Repression of Pericentromeric Genes: Mmp3, Mmp10 and Mmp13, in Mouse Fibroblasts. J Mol Biol. 2020; May 1;432(10):3222-3238. doi: 10.1016/j.jmb.2020.03.013. IF: 5,469.
  23. Ioannidis AG, Blanco-Portillo J, Sandoval K, Hagelberg E, Miquel-Poblete JF, Moreno-Mayar JV, Rodríguez-Rodríguez JE, Quinto-Cortés CD, Auckland K, Parks T, Robson K, Hill AVS, Avila-Arcos MC, Sockell A, Homburger JR, Wojcik GL, Barnes KC, Herrera L, Berríos S, Acuña M, Llop E, Eng C, Huntsman S, Burchard EG, Gignoux CR, Cifuentes L, Verdugo RA, Moraga M, Mentzer AJ, Bustamante CD, Moreno-Estrada A. Native American gene flow into Polynesia predating Easter Island settlement. Nature. 2020; 583(7817):572-577. doi: 10.1038/s41586-020-2487- 2. IF: 49,962.
  24. Castro-Santos P, Verdugo RA, Alonso-Arias R, Gutiérrez MA, Suazo J, Aguillón JC, Olloquequi J, Pinochet C, Lucia A, Quiñones LA, Díaz-Peña R. Association analysis in a Latin American population revealed ethnic differences in rheumatoid arthritis-associated SNPs in Caucasian and Asian populations. Sci Rep. 2020 May 12;10(1):7879. doi: 10.1038/s41598-020-64659-0. IF: 4,379.
  25. Verdugo RA, Di Genova A, Herrera L, Moraga M, Acuña M, Berríos S, Llop E, Valenzuela CY, Bustamante ML, Digman D, Symon A, Asenjo S, López P, Blanco A, Suazo J, Barozet E, Caba F, Villalón M, Alvarado S, Cáceres D, Salgado K, Portales P, Moreno-Estrada A, Gignoux CR, Sandoval K, Bustamante CD, Eng C, Huntsman S, Burchard EG, Loira N, Maass A, Cifuentes L. Development of a small panel of SNPs to infer ancestry in Chileans that distinguishes Aymara and Mapuche components. Biol Res. 2020 Apr 16;53(1):15. doi: 10.1186/s40659-020-00284-5. IF: 5,612.
  26. Sagredo EA, Sagredo AI, Blanco A, Rojas De Santiago P, Rivas S, Assar R, Pérez P, Marcelain K, Armisén R. ADAR1 Transcriptome editing promotes breast cancer progression through the regulation of cell cycle and DNA damage response. Biochim Biophys Acta Mol Cell Res. 2020 Aug;1867(8):118716. doi: 10.1016/j.bbamcr.2020. 118716. IF: 4,739.
  27. Scherer D, Dávila López MD, Goeppert B, Abrahamsson S, González Silos RG, Nova I, Marcelain K, Roa JC, Ibberson D, Umu SU, Rounge TB, Roessler S, Bermejo JL. RNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling. Cancers (Basel). 2020 Sep 3;12(9):2510. doi: 10.3390/cancers12092510. IF: 6,639.
  28. Boekstegers F, Marcelain K, Barahona Ponce C, Baez Benavides PF, Müller B, de Toro G, Retamales J, Barajas O, Ahumada M, Morales E, Rojas A, Sanhueza V, Loader D, Rivera MT, Gutiérrez L, Bernal G, Ortega A, Montalvo D, Portiño S, Bertrán ME, Gabler F, Spencer L, Olloquequi J, González Silos R, Fischer C, Scherer D, Jenab M, Aleksandrova K, Katzke V, Weiderpass E, Moradi T, Fischer K, Bossers W, Brenner H, Hveem K, Eklund N, Völker U, Waldenberger M, Fuentes Guajardo M, Gonzalez-Jose R, Bedoya G, Bortolini MC, Canizales S, Gallo C, Ruiz Linares A, Rothhammer F, Lorenzo Bermejo J. ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans. Cancer Epidemiol. 2020 Apr;65:101643. doi: 10.1016/j.canep.2019.101643. IF: 2,984.
  29. Tapia MC, Cardemil FM. Supervivencia de cirugía de rescate en carcinoma escamoso de orofaringe. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2020; 80: 184-192. IF: 0,000.
  30. Segall DK., Flatman SJ, Cardemil FM. Ultrasonido realizado por el otorrinolaringólogo-cirujano de cabeza y cuello: revisión de la literatura. Rev. Otorrinolaringol. Cir. Cabeza Cuello 2020; 80: 522-530. IF: 0,000.

-Año 2019-

  1. Arenas A, Serrano C, Quiñones L, Harris P, Sandoval M, Lavanderos M, Sepúlveda R, Maquilón S, Echeverría A, Ríos C, Fuentes-López E, Rojas L, Jorquera A, Pizarro M, Camargo MC, Riquelme A. High prevalence of clarithromycin resistance and effect on Helicobacter pylori eradication in a population from Santiago, Chile: cohort study and meta-analysis. Sci Rep. 2019 Dec 27;9(1):20070. doi: 10.1038/s41598-019-56399-7. IF: 4,379.
  2. López-Cortés A, Paz-y-Miño C. 1, Jaramillo-Koupermann G., García-Cárdenas J., Quiñones LA, Cayún JP, Soria NW. Pharmacogenomics and precision medicine in colorectal cancer: biomarkers and allele frequencies in populations worldwide. Pharmacogenomics J. 2019 Oct 15. doi: 10.1038/s41397-019-0102-4. IF: 3,550.
  3. López-Moncada F, Torres MJ, Castellón EA, Contreras HR. Secreted protein acidic and rich in cysteine (SPARC) induces epithelial-mesenchymal transition, enhancing migration and invasion, and is associated with high Gleason score in prostate cancer. Asian J Androl. 2019 Nov-Dec;21(6):557-564. doi: 10.4103/aja.aja_23_19. IF: 3,285.
  4. Aedo-Aguilera V, Carrillo-Beltrán D, Calaf GM, Muñoz JP, Guerrero N, Osorio JC, Tapia JC, León O, Contreras HR, Aguayo F. Curcumin decreases epithelial- mesenchymal transition by a Pirin‑dependent mechanism in cervical cancer cells. Oncol Rep. 2019 Nov;42(5):2139-2148. doi: 10.3892/or.2019.7288. IF: 3,906.
  5. Landskron G, De la Fuente López M, Dubois-Camacho K, Díaz-Jiménez D, Orellana-Serradell O, Romero D, Sepúlveda SA, Salazar C, Parada-Venegas D, Quera R, Simian D, González MJ, López-Köstner F, Kronberg U, Abedrapo M, Gallegos I, Contreras HR, Peña C, Díaz-Araya G, Roa JC, Hermoso MA. Corrigendum: Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer. Front Immunol. 2019 Sep 24; 10:2149. doi: 10.3389/fimmu. 2019.02149. eCollection 2019. IF: 7,561.
  6. Grijalva-Avila J, Villanueva-Fierro I, Lares-Asseff I, Chairez-Hernández I, Rivera-Sanchez G, Martínez-Estrada S, Martínez-Rivera I, Quiñones LA, Loera-Castañeda V. Milk intake and IGF-1 rs6214 polymorphism as protective factors to obesity. Int J Food Sci Nutr. 2019 Sep 18:1-6. doi:10.1080/ 09637486.2019.1666805. IF: 3,483.
  7. Orellana-Serradell O, Herrera D, Castellón EA, Contreras HR. The transcription factor ZEB1 promotes chemoresistance in prostate cancer cell lines. Asian J Androl. 2019 Sep-Oct;21(5):460-467. doi: 10.4103/aja.aja_1_19. IF: 3,285.
  8. Alvarado AT, Muñoz AM, Loja B, Miyasato JM, García JA, Cerro RA, Quiñones LA, Varela N. Study of the allelic variants CYP2C9*2 and CYP2C9*3 in samples of the Peruvian mestizo population. 2019 Sep 1;39(3):601-610. doi:10.7705/biomedica.4636. IF: 0,935.
  9. Roco A, Lavanderos A, Cayún JP, Acevedo C, Celedón C, Rubilar JC, Sandoval C, Cerpa L, García-Martín E, Agúndez JA, Esguevillas G, Amo G, Canepa A, Cerda B, Peña K, Cáceres DD, Varela N, Quiñones LA. The role of phase I and II genetic polymorphisms, smoking, alcohol and cancer family history, in the risk of developing testicular cancer. Pharmacogenet Genomics. 2019; 29(7):159-166. doi: 10.1097/ FPC.0000000000000379. IF: 2.089.
  10. Castro I, Albornoz N, Aguilera S, Barrera MJ, González S, Núñez M, Carvajal P, Jara D, Lagos C, Molina C, Urzúa U, Hermoso MA, González MJ. Aberrant MUC1 accumulation in salivary glands of Sjögren's syndrome patients is reversed by TUDCA in vitro. Rheumatology (Oxford). 2019 Aug 3. pii: kez316. doi:10.1093/ rheumatology/kez316. IF: 7,580.
  11. Landskron G, De la Fuente López M, Dubois-Camacho K, Díaz-Jiménez D, Orellana-Serradell O, Romero D, Sepúlveda SA, Salazar C, Parada-Venegas D, Quera R, Simian D, González MJ, López-Köstner F, Kronberg U, Abedrapo M, Gallegos I, Contreras HR, Peña C, Díaz-Araya G, Roa JC, Hermoso MA. Interleukin 33/ST2 Axis Components Are Associated to Desmoplasia, a Metastasis-Related Factor in Colorectal Cancer. Front Immunol. 2019 Jun 21;10:1394. doi:10.3389/fimmu.2019.01394. eCollection 2019. Erratum in: Front Immunol. 2019 Sep 24;10:2149. IF: 7,561.
  12. Castellón EA. Patient-derived organoids: New co-clinical model to predict treatment response in cancer? Oral Dis. 2019 May;25(4):928-930. doi:10.1111/odi.12988. IF: 3,511.
  13. Lavanderos MA, Cayún JP, Roco Á, Sandoval C, Cerpa L, Rubilar JC, Cerro R, Molina-Mellico S, Celedón C, Cerda B, García-Martín E, Agúndez JAG, Acevedo C, Peña K, Cáceres DD, Varela N, Quiñones LA. Association Study Among Candidate Genetic Polymorphisms and Chemotherapy-Related Severe Toxicity in Testicular Cancer Patients. Front Pharmacol. 2019 Mar 8;10:206. doi:10.3389/fphar.2019.00206. eCollection 2019. IF: 5,810.
  14. Sagredo AI, Sagredo EA, Pola V, Echeverría C, Andaur R, Michea L, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 channel is involved in regulating epithelial to mesenchymal transition, migration, and invasion of prostate cancer cell lines. J Cell Physiol. 2019 Mar;234(3):2037-2050. doi: 10.1002/jcp.27371. IF: 6,384.
  15. Cortés J, Hidalgo J, Aguilera S, Castro I, Brito M, Urra H, Pérez P, Barrera MJ, Carvajal P, Urzúa U, González S, Molina C, Bahamondes V, Hermoso M, González MJ. Synaptotagmin-1 overexpression under inflammatory conditions affects secretion in salivary glands from Sjögren's syndrome patients. J Autoimmun. 2019 Feb;97:88-99. doi: 10.1016/j.jaut.2018.10.019. IF: 7,094.
  16. Herrera D, Orellana-Serradell O, Villar P, Torres MJ, Paciucci R, Castellón EA, Contreras HR. Silencing of the transcriptional factor ZEB1 alters the steroidogenic pathway, and increases the concentration of testosterone and DHT in DU145 cells. Oncol Rep. 2019 Feb;41(2):1275-1283. doi: 10.3892/or.2018.6885. IF: 3,906.
  17. Nieto E, Suarez M, Roco Á, Rubilar JC, Tamayo F, Rojo M, Verón G, Sepúlveda J, Mejías F, Salas P, Góngora M, Andrade P, Canales A, Carabantes J, Cruz D, Contreras E, Pavez D, Charo P, Bravo G, Calderón J, Gallardo C, Vega P, Quiñones LA. Anticoagulation Management With Coumarinic Drugs in Chilean Patients. Clin Appl Thromb Hemost. 2019; 25:1076029619834342. doi: 10.1177 /1076029619834342. IF: 2,389.
  18. Walton-Diaz A, Madariaga-Venegas M, Aviles N, Roman JC, Gallegos I, Burotto M. Developing a National Center of Excellence for Prostate Imaging. Curr Urol Rep. 2019 Sep 2;20(10):59. doi: 10.1007/s11934-019-0923-3. IF: 3,092.
  19. Renner, A., Samtani, S. R., Marín, A., Burotto, M. Is Cytoreductive Nephrectomy Still a Standard of Care in Metastatic Renal Cell Carcinoma? Journal of Kidney Cancer and VHL, 2019, 6(1), 1-7. https://doi.org/10.15586/jkcvhl.2019.114. IF: 0,430.
  20. Contreras HR, García. Inter-species variability of okadaic acid group toxicity in relation to the content of fatty acids detected in different marine vectors. C. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2019 Mar; 36(3):464-482. doi: 10.1080/19440049. 2019.1569265. IF: 2,487.

 -Año 2018-

  1. Quiñones LA, Remírez D, Rojo M. Applicability of Pharmacogenetic Drug-gene pair strategy in Clinical studies: Regulatory considerations in Latin America. Clinical Pharmacology and Translational Medicine. 2018, Volume 2(2): 108 – 111. IF: 0.000.
  2. Alvarado-Yarasca A, Sullón Dextre L, Salazar-Granara A, Loja Herrera B, Miyasato MJ., Li-Amenero C, Miguel-Ato R, Quiñones-Sepúlveda L, Varela-Figueroa N, Espinoza-Alegre O. Estudio de las variantes alélicas del gen CYP2C9 y monitorización clínica de valproato en plasma como fundamento de la medicina personalizada. Diagnóstico, 2018; Vol. 57(2), 73-78. IF: 0,000.
  3. González-Martínez F, Sánchez-Rodas D, Cáceres DD, Martínez MF, Quiñones LA, Johnson-Restrepo B. Arsenic exposure, profiles of urinary arsenic species, and polymorphism effects of glutathione-s-transferase and metallothioneins. 2018 Dec;212:927-936. doi:10.1016/j.chemosphere.2018.08.139. IF: 7,086.
  4. Lagos C, Carvajal P, Castro I, Jara D, González S, Aguilera S, Barrera MJ, Quest AFG, Bahamondes V, Molina C, Urzúa U, Hermoso MA, Leyton C, González MJ. Association of high 5-hydroxymethyl cytosine levels with Ten Eleven Translocation 2 overexpression and inflammation in Sjögren's syndrome patients. Clin Immunol. 2018 Nov;196:85-96. doi: 10.1016/j.clim.2018.06.002. IF: 3,969.
  5. Roco Á, Cerda B, Cayún JP, Lavanderos A, Rubilar JC, Cerro R, Acevedo C, Cáceres D, Varela N, Quiñones LA. [Pharmacogenetics, tobacco, alcohol and its effect on the risk development cancer]. Rev Chil Pediatr. 2018 Aug;89(4):432-440. doi: 10.4067/S0370-41062018005000709. Review. IF: 0,270.
  6. Farfán N, Ocarez N, Castellón EA, Mejía N, de Herreros AG, Contreras HR. The transcriptional factor ZEB1 represses Syndecan 1 expression in prostate cancer. Sci Rep. 2018 Jul 31;8(1):11467. doi: 10.1038/s41598-018-29829-1. IF: 4,379.
  7. Sepúlveda D, Barrera MJ, Castro I, Aguilera S, Carvajal P, Lagos C, González S, Albornoz N, Bahamondes V, Quest AFG, Urzúa U, Molina C, Leyton C, Hermoso MA, González MJ. Impaired IRE1α/XBP-1 pathway associated to DNA methylation might contribute to salivary gland dysfunction in Sjögren's syndrome patients. Rheumatology (Ox). 2018 Jun 1;57(6):1021-1032. doi: 10.1093/rheumatology/key021. IF: 7,580.
  8. Andaur R, Tapia JC, Moreno J, Soto L, Armisen R, Marcelain K. Differential miRNA expression profiling reveals miR-205-3p to be a potential radiosensitizer for low- dose ionizing radiation in DLD-1 cells. Oncotarget. 2018 May 29;9(41):26387-26405. doi: 10.18632/oncotarget.25405. eCollection. IF: 5,168.
  9. Calaf GM, Urzua U, Termini L, Aguayo F. Oxidative stress in female cancers. Oncotarget. 2018 May 4;9(34):23824-23842. doi: 10.18632/oncotarget.25323. eCollection. IF: 5,168.
  10. Orellana-Serradell O, Herrera D, Castellón EA, Contreras HR. The transcription factor ZEB1 promotes an aggressive phenotype in prostate cancer cell lines. Asian J Androl. 2018 May-Jun;20(3):294-299. doi: 10.4103/aja.aja_61_17. IF: 3,285.
  11. Urzúa U, Chacon C, Espinoza R, Martínez S, Hernandez N. Parity-Dependent Hemosiderin and Lipofuscin Accumulation in the Reproductively Aged Mouse Ovary. Anal Cell Pathol (Amst). 2018 Mar 15;2018:1289103. doi: 10.1155/2018/1289103. eCollection. IF: 2,916.
  12. Sagredo AI, Sagredo EA, Cappelli C, Báez P, Andaur RE, Blanco C, Tapia JC, Echeverría C, Cerda O, Stutzin A, Simon F, Marcelain K, Armisén R. TRPM4 regulates Akt/GSK3-β activity and enhances β-catenin signaling and cell proliferation in prostate cancer cells. Mol Oncol. 2018 Feb;12(2):151-165. doi: 10.1002/1878-0261.12100. IF: 6,603.
  13. Sagredo EA, Blanco A, Sagredo AI, Pérez P, Sepúlveda-Hermosilla G, Morales F, Müller B, Verdugo R, Marcelain K, Harismendy O, Armisén R. ADAR1-mediated RNA-editing of 3'UTRs in breast cancer. Biol Res. 2018 Oct 5;51(1):36. doi: 10.1186/s40659-018-0185-4. IF: 5,612.
  14. Ampuero S, Andaur R, Milano M, Moreno M, Lizama L, Larrañaga C, Urzúa U. Time-course of transcriptome response to respiratory syncytial virus infection in lung epithelium cells. Acta Virol. 2018;62(3):310-325. doi: 10.4149/av_2018_225. IF: 1,162.

 -Año 2017-

  1. Carrillo D, Muñoz JP, Huerta H, Leal G, Corvalán A, León O, Calaf GM, Urzúa U, Boccardo E, Tapia JC, Aguayo F. Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells. Open Biol. 2017 Nov;7(11). pii: 170111. doi: 10.1098/rsob.170111. IF: 6,411.
  2. Urzua U, Chacon C, Lizama L, Sarmiento S, Villalobos P, Kroxato B, Marcelain K, Gonzalez MJ. Parity History Determines a Systemic Inflammatory Response to Spread of Ovarian Cancer in Naturally Aged Mice. Aging Dis. 2017 Oct 1;8(5):546-557. doi: 10.14336/AD.2017.0110. eCollection. IF: 6,745.
  3. Lorenzo Bermejo J, Boekstegers F, González Silos R, Marcelain K, Baez Benavides P, Barahona Ponce C, Müller B, Ferreccio C, Koshiol J, Fischer C, Peil B, Sinsheimer J, Fuentes Guajardo M, Barajas O, Gonzalez-Jose R, Bedoya G, Cátira Bortolini M, Canizales-Quinteros S, Gallo C, Ruiz Linares A, Rothhammer F. Subtypes of Native American ancestry and leading causes of death: Mapuche ancestry-specific associations with gallbladder cancer risk in Chile. PLoS Genet. 2017 May 25;13(5):e1006756. doi: 10.1371/journal.pgen.1006756. eCollection. IF: 5,917.
  4. López-Cortés A, Guerrero S, Redal MA, Alvarado AT, Quiñones LA. State of Art of Cancer Pharmacogenomics in Latin American Populations. Int J Mol Sci. 2017 May 23;18(6). pii: E639. doi: 10.3390/ijms18060639. Review. IF: 5,923.
    IF= Factor de Impacto ISI. Se consideró el IF más reciente (2020).

 

Tendencia Factor de Impacto (IF)                             Tendencia número de publicaciones

 

-Libros y Capítulos de libros:

Libros

  1. Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  2. Quiñones L.A. Pharmacogenomics in Latin America: challenges and opportunities. Nova Science Publisher, New York, USA. Editor. ISBN: 978-1-53611-031-9. https://www.novapublishers.com/catalog/product_info.php?products_id=61267.

Capítulos de Libros

  1. Pharmacogenomics: Basis and milestones. Leslie C. Cerpa, Nelson M. Varela, Matías M. Martínez, Luis A. Quiñones. In The ADME Encyclopedia. Ed. Talevi A. Ed. Springer, 2021. Springer Nature Switzerland AG 2021. In press.
  2. Pharmacogenomics: Genetic Polymorphisms. Nelson M. Varela, Leslie C. Cerpa, Matías M. Martínez, Luis A. Quiñones. In The ADME Encyclopedia. Ed. Talevi A. Ed. Springer, 2021. Springer Nature Switzerland AG 2021. In press.
  3. Pharmacokinetic polymorphisms. Matías M. Martínez, Leslie C. Cerpa, Nelson M. Varela, Luis A. Quiñones. In The ADME Encyclopedia. Ed. Talevi A. Ed. Springer, 2021. Springer Nature Switzerland AG 2021. In press.
  4. Pharmacodynamic polymorphisms. Matías F. Martínez, Leslie C. Cerpa, Nelson M. Varela, Luis A. Quiñones. In The ADME Encyclopedia. Ed. Talevi A. Ed. Springer, 2021. Springer Nature Switzerland AG 2021. In press.
  5. Pharmacogenomics: Challenges and future perspectives. Luis A. Quiñones, Matías M. Martínez, Leslie C. Cerpa, Nelson M. Varela. In The ADME Encyclopedia. Ed. Talevi A. Ed. Springer, 2021. Springer Nature Switzerland AG 2021. In press.
  6. Hacia la incorporación de guías clínicas de farmacogenómica en América Latina. Luis A. Quiñones, Ismael Lares-Asseff, Angel Alvarado-Yarasca. Capítulo 1, en Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  7. Farmacogenómica en la práctica psiquiátrica: iniciativas en Latinoamérica. Lina Ortiz L., Mauricio Moreno, Luis A. Quiñones. Capítulo 6, en Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  8. Farmacogenética cardiovascular: aplicaciones clínicas en latinoamérica. Ángela Roco, Luis A. Quiñones, Marcelo Suárez. Capítulo 7, en Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  9. Farmacogenómica del cáncer: un paso más hacia la medicina de precisión en América Latina. Andrés López-Cortés, César Paz-y-Miño, Santiago Guerrero, Patricia Guevara-Ramírez, Gabriela Pérez-M, María Ana Redal, Vívian D’Afonseca, Marcela Salazar, Luis Abel Quiñones. Capítulo 11, en Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  10. Direcciones futuras: desafíos, oportunidades y limitaciones. Maria A. Redal, Luis A. Quiñones. Capítulo 18, en Quiñones L.A. & Redal M.A. Farmacogenómica y Medicina Personalizada en Latinoamérica. Editorial Académica Española. Madrid, España. 2019. ISBN: 978-620-0-05644-3.
  11. Current status of cancer pharmacogenomics. Chapter 22. Juan P. Cayún and Luis A. Quiñones. In: Precision Medicine for Investigators, Practitioners and Providers. Eds. Joel Faintuch. Elsevier 2019. ISBN: 9780128191781, https://doi.org/10.1016/B978-0-12-819178-1.00022-8.
  12. Relationship between pharmacokinetics and pharmacogenomics, and its impact on drug choice and dose regimens. Matías F. Martínez, Luis A. Quiñones. In: ADME processes and their impact on pharmaceutical sciences, Ed. Talevi A. Ed. Springer, 2018. https://link.springer.com/book/10.1007%2F978-3-319-99593-9#about. DOI https://doi.org/10.1007/978-3-319-99593-9. Springer Nature Switzerland AG 2018. Print ISBN 978-3-319-99592-2, Online ISBN 978-3-319-99593-9.
  13. Toward incorporation of Clinical Guidelines of Pharmacogenomics in Latin America. Chapter 1. Luis A. Quiñones, Ismael Lares-Asseff in Phamacogenomics in Latin America: challenges and opportunities. Nova Science Publisher, New York, USA, 2017.
  14. Pharmacogenomics in Psichiatry Practice. Chapter 7. Lina Ortiz, Mauricio Moreno & Luis A. Quiñones. in Phamacogenomics in Latin America: challenges and opportunities. Nova Science Publisher, New York, USA. 2017.
  15. Cardiovascular Pharmacogenomics. Chapter 8. Angela M. Roco, Carla E. Miranda, Luis A. Quiñones. in Latin America: challenges and opportunities. Nova Science Publisher, New York, USA. 2017.
  16. Future Directions: Challenges, opportunities and limitations. Chapter 13. Luis A. Quiñones & Maria A. Redal. in Phamacogenomics in Latin America: challenges and opportunities. Nova Science Publisher, New York, USA, 2017.
  17. Farmacogenómica y Medicina personalizada en Latinoamérica. Publicación conjunta SOLFAGEM y RELIVAF-CYTED. Editorial Académica Española (2020) - ISBN: 978-620-0-05644-3. Capítulo 8: Farmacogenética de la terapia Antirretroviral en pacientes que viven con VIH, y situación latinoamericana (páginas: 243 – 288). Fernando Bernal / Nelson Varela (Autor de correspondencia).
  18. Pharmacogenomics in Latin America. Challenges and Opportunities. Editor: Luis A. Quiñones. Pharmacology – Research, Safety Testing and Regulation. Published by Nova Science Publishers, Inc. New York, USA (2017). ISBN: 978-1-53611-050-0 (eBook) - Library of Congress Control Number: 2017934375. Chapter 10: Pharmacogenomics of Antiretroviral therapy in Latin America (pages: 169 – 194). Fernando Bernal, Gabriel Llull, Sebastian Archiles, Nelson Varela (Corresponding author).